AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 253: G284-G289, 1987;
0193-1857/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tseng, C. C.
Right arrow Articles by Johnson, L. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tseng, C. C.
Right arrow Articles by Johnson, L. R.

AJP - Gastrointestinal and Liver Physiology, Vol 253, Issue 3 284-G289, Copyright © 1987 by American Physiological Society

ARTICLES

Hormonal effects on development of the secretory apparatus of parietal cells

C. C. Tseng, K. L. Schmidt and L. R. Johnson

The effect of corticosterone and thyroxine on the development of parietal cells was studied in 20-day-old rats. Either corticosterone or thyroxine injection significantly increased the amount of mitochondria, tubulovesicles, and intracellular canaliculi in normal rat pup parietal cells. However, the ultrastructure of parietal cells did not change when rats were adrenalectomized or made hypothyroid by propylthiouracil (PTU) during the first week of life. Corticosterone had the same effect in hypothyroid rats as in normal rats, increasing the volume fraction of mitochondria and the surface density of tubulovesicles and intracellular canaliculi in the parietal cell. However, thyroxine failed to do so in adrenalectomized animals. When 20-day-old adrenalectomized or hypothyroid rats were challenged with secretagogues, there was no increase in maximal acid output over the basal secretory rate, while normal rats showed a 40-50% increase. We conclude that 1) normal parietal cells respond to additional thyroxine or corticosterone with increases in volume fraction of mitochondria and surface density of tubulovesicles and intracellular canaliculi; 2) the dramatic decreases in acid secretion observed in adrenalectomized or PTU-treated rats are not explained by the morphology of parietal cells that remains normal; 3) the effect of thyroxine on the development of acid secretion is mediated by corticosterone; and 4) unlike chief cells the morphological development of parietal cells does not appear to depend on corticosterone or thyroxine after postnatal day 7.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
P. Kirchhoff, C. A. Wagner, F. Gaetzschmann, K. Radebold, and J. P. Geibel
Demonstration of a functional apical sodium hydrogen exchanger in isolated rat gastric glands
Am J Physiol Gastrointest Liver Physiol, December 1, 2003; 285(6): G1242 - G1248.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online