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Am J Physiol Gastrointest Liver Physiol 254: G489-G494, 1988;
0193-1857/88 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 254, Issue 4 489-G494, Copyright © 1988 by American Physiological Society

ARTICLES

Contractile effects of manganese on taenia of guinea pig cecum

T. W. Lategan and A. F. Brading
Department of Pharmacology, Oxford University, United Kingdom.

The present study was undertaken to examine Mn as a contractile agent in its own right in the absence of extracellular Ca and after the depletion of Ca from agonist-releasable stores. The results show that isolated strips of taenia coli depolarized by high-K, Ca-free solution will contract when Mn is present. Similarly, carbachol will evoke contractions in tissues incubated in Ca-free, Mn-containing solutions. In addition, it seems possible to stimulate contraction by releasing Mn from an agonist-releasable intracellular store in the absence of extracellular Ca and Mn. Therefore the possibility exists that cations employed as Ca antagonists may in fact support contraction.


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