AJP - Gastrointestinal and Liver Physiology, Vol 254, Issue 4 566-G574, Copyright © 1988 by American Physiological Society
An autoradiographic study of regional distribution of gastric mucosal blood flow
W. J. Angerson, J. G. Geraghty and D. C. Carter
University Department of Surgery, Royal Infirmary, Glasgow, United Kingdom.
Iodo[14C]antipyrine autoradiography was used to measure gastric mucosal
blood flow in anesthetized rats and to study regional distribution. Blood
flows of 61 +/- 8 ml.100 g-1.min-1 (means +/- SE) in corpus and 84 +/- 9
ml.100 g-1.min-1 in antral mucosa compared well with previously reported
measurements by hydrogen clearance. Blood flow in the crests of corpus
mucosal folds was significantly higher than in the valleys between folds,
indicating that the greater susceptibility of the former areas to acute
injury, documented in several studies, is not associated with a perfusion
defect in the resting stomach. Corpus mucosal blood flow was also higher in
the side walls of the stomach than in the greater curvature region, and in
distal than in proximal locations. No systematic regional variations within
antral mucosa were demonstrated.
