AJP - Gastrointestinal and Liver Physiology, Vol 255, Issue 5 535-G541, Copyright © 1988 by American Physiological Society
Role of pancreatic polypeptide in the regulation of pancreatic exocrine secretion in dogs
K. Shiratori, K. Y. Lee, T. M. Chang, Y. H. Jo, D. H. Coy and W. Y. Chey
Isaac Gordon Center for Digestive Diseases and Nutrition, Genesee Hospital, Rochester, New York 14607.
The effect of intravenous infusion of synthetic human pancreatic
polypeptide (HPP) or a rabbit anti-PP serum on pancreatic exocrine
secretion was studied in 10 dogs with gastric and Thomas duodenal cannulas.
The infusion of HPP, at a dose of 1 microgram.kg-1.h-1, achieved a plasma
PP concentration that mimicked the peak plasma concentration of PP in both
interdigestive and postprandial states. This dose of HPP significantly
inhibited pancreatic secretion in the interdigestive state. By contrast,
immunoneutralization of circulating PP by a rabbit anti-PP serum resulted
in significant increases (P less than 0.05) in both interdigestive and
postprandial pancreatic secretion, including water, bicarbonate, and
protein. The increase in the pancreatic secretion paralleled a decrease in
circulating PP level, which lasted for as long as 5 days. Furthermore, the
anti-PP serum blocked the inhibitory action of exogenous HPP on pancreatic
exocrine secretion. The present study indicates that endogenous PP plays a
significant role in the regulation of the pancreatic exocrine secretion in
both interdigestive and digestive states. Thus we conclude that PP is
another hormone regulating pancreatic exocrine secretion in dogs.
