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Am J Physiol Gastrointest Liver Physiol 255: G709-G712, 1988;
0193-1857/88 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 255, Issue 6 709-G712, Copyright © 1988 by American Physiological Society

ARTICLES

Splanchnic nerve stimulation inhibits duodenal HCO3- secretion in the rat

C. Jonson and L. Fandriks
Department of Physiology, University of Goteborg, Sweden.

Sympathoadrenergic inhibition of HCO3- secretion by the duodenal mucosa was studied in chloralose anesthetized rats. Duodenal HCO3- secretion was measured in situ by pH-stat titration. Direct efferent electrical stimulation of the cut splanchnic nerves (10 Hz, supramaximal intensity) inhibited the duodenal alkaline output by approximately 50%. This inhibitory response was blocked by the administration of either the adrenolytic agent guanethidine or the alpha 2-adrenoceptor antagonist yohimbine. However, neither the alpha 1-adrenoceptor antagonist prazosin nor the beta-adrenoceptor antagonist propranolol blocked the response to splanchnic nerve stimulation. The present data suggest that electrical splanchnic nerve stimulation inhibits duodenal HCO3- secretion via activation of adrenergic nerve fibers and alpha 2-adrenoceptors within the peripheral nervous system.




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