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Am J Physiol Gastrointest Liver Physiol 256: G532-G539, 1989;
0193-1857/89 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 256, Issue 3 532-G539, Copyright © 1989 by American Physiological Society

ARTICLES

Amino acid transport across the hen colon: interactions between leucine and lysine

B. G. Munck
Panum Institute, University of Copenhagen, Denmark.

Several neutral amino acids such as leucine added on the mucosal side stimulate the mucosal-to-serosal flux (Jm----s) of cationic amino acids such as lysine. We show here in the colon of the NaCl-loaded hen that this is a result of interactions at the basolateral membrane. The hen colon was used because it tolerates prolonged incubation and has a relatively short tip of villus-to-muscularis mucosa distance. Two models have been proposed for the interpretation of the effect of mucosal-side addition of leucine on Jm----s of lysine: 1) one of an allosteric effect of cytoplasmic leucine on lysine efflux across the basolateral membrane; and 2) one of asymmetric heteroexchange of leucine from outside the basolateral membrane for cytoplasmic lysine. These two models were tested by measurements of influx across the brush-border membrane, of Jm----s and serosal-to-mucosal flux, and of steady state epithelial uptake of leucine and lysine. The data favor the model of allosteric interaction and are inconsistent with the model of asymmetric heteroexchange.


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R. DEVES and C. A. R. BOYD
Transporters for Cationic Amino Acids in Animal Cells: Discovery, Structure, and Function
Physiol Rev, April 1, 1998; 78(2): 487 - 545.
[Abstract] [Full Text] [PDF]


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