AJP - Gastrointestinal and Liver Physiology, Vol 257, Issue 4 517-G523, Copyright © 1989 by American Physiological Society

ARTICLES

Cholinergic control of smooth muscle peristalsis in the cat esophagus

E. L. Blank, B. Greenwood and W. J. Dodds
Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226.

The aim of this study was to examine in detail the effects of selective cholinergic and other pharmacological antagonists on primary and secondary peristalsis in the smooth muscle of the cat esophagus in order to fully characterize the cholinergic contribution to peristalsis in this species. Primary and secondary peristalsis in the smooth muscle part of the feline esophagus was completely abolished by atropine, 4-dephenylacetoxy-N-methylpiperidine methiodide (4-DAMP) (a selective M2 muscarinic antagonist), hexamethonium, and high doses of nicotine. Pirenzepine (a selective M1 muscarinic antagonist), propranolol, and phentolamine were without effect, as were naloxone, methysergide, and pyrilamine. From these findings we conclude that primary and secondary peristalsis in feline esophageal smooth muscle involves nicotinic ganglionic neurotransmission as well as postganglionic release of acetylcholine that acts directly on muscarinic receptors located on the smooth muscle. Peristalsis in esophageal striated muscle does not involve either synaptic transmission or muscarinic receptors.

This article has been cited by other articles:

				Jan. D. Huizinga, D. E. Reed, I. Berezin, X.-Y. Wang, Diana. T. Valdez, L. W. C. Liu, and N. E. Diamant Survival dependency of intramuscular ICC on vagal afferent nerves in the cat esophagus Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R302 - R310. [Abstract] [Full Text] [PDF]

				A. Muinuddin, K. Naqvi, L. Sheu, H. Y. Gaisano, and N. E. Diamant Regional differences in cholinergic regulation of potassium current in feline esophageal circular smooth muscle Am J Physiol Gastrointest Liver Physiol, June 1, 2005; 288(6): G1233 - G1240. [Abstract] [Full Text] [PDF]

				A. Muinuddin, S. Xue, and N. E. Diamant Regional differences in the response of feline esophageal smooth muscle to stretch and cholinergic stimulation Am J Physiol Gastrointest Liver Physiol, December 1, 2001; 281(6): G1460 - G1467. [Abstract] [Full Text] [PDF]

				A. Jean Brain Stem Control of Swallowing: Neuronal Network and Cellular Mechanisms Physiol Rev, April 1, 2001; 81(2): 929 - 969. [Abstract] [Full Text] [PDF]

				H. G. Preiksaitis, P. S. Krysiak, T. Chrones, V. Rajgopal, and L. G. Laurier Pharmacological and Molecular Characterization of Muscarinic Receptor Subtypes in Human Esophageal Smooth Muscle J. Pharmacol. Exp. Ther., December 1, 2000; 295(3): 879 - 888. [Abstract] [Full Text]

				J. Wang, P. S. Krysiak, L. G. Laurier, S. M. Sims, and H. G. Preiksaitis Human esophageal smooth muscle cells express muscarinic receptor subtypes M1 through M5 Am J Physiol Gastrointest Liver Physiol, November 1, 2000; 279(5): G1059 - G1069. [Abstract] [Full Text] [PDF]

				H. G. Preiksaitis and N. E. Diamant Myogenic mechanism for peristalsis in the cat esophagus Am J Physiol Gastrointest Liver Physiol, August 1, 1999; 277(2): G306 - G313. [Abstract] [Full Text] [PDF]

				H. G. Preiksaitis and L. G. Laurier Pharmacological and Molecular Characterization of Muscarinic Receptors in Cat Esophageal Smooth Muscle J. Pharmacol. Exp. Ther., May 1, 1998; 285(2): 853 - 861. [Abstract] [Full Text]

				W. Y. Lu and D. Bieger Vagovagal reflex motility patterns of the rat esophagus Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1998; 274(5): R1425 - R1435. [Abstract] [Full Text] [PDF]

				W. Y. Lu and D. Bieger Vagal afferent transmission in the NTS mediating reflex responses of the rat esophagus Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1998; 274(5): R1436 - R1445. [Abstract] [Full Text] [PDF]