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Am J Physiol Gastrointest Liver Physiol 259: G179-G183, 1990;
0193-1857/90 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 259, Issue 2 179-G183, Copyright © 1990 by American Physiological Society

ARTICLES

Effects of hypovolemia on blood flow, arterial [HCO3-], and HCO3- output in the rat duodenum

C. Jonson, L. Holm, T. Jansson and L. Fandriks
Department of Physiology, University of Goteborg, Sweden.

The effects of bleeding-induced hypovolemia on duodenal blood flow (microsphere technique), arterial [HCO3-], and duodenal HCO3- secretion (in situ titration) were investigated in chloralose-anesthetized rats. A 10% decrease in blood volume reduced duodenal HCO3- secretion by 44%, duodenal blood flow by 31%, and arterial [HCO3-] by 11%. In a group with cervically cut vagal nerves, basal duodenal HCO3- secretion was greater than 50% lower compared with controls. Basal blood flow and arterial [HCO3-] were on similar levels as in nonvagotomized animals. Furthermore, bleeding failed to lower duodenal alkaline output in rats with cut vagal nerves, although blood flow and arterial [HCO3-] were reduced to a similar extent as in the vagally intact controls. In a yohimbine-treated group, a 10% bleeding reduced duodenal blood flow by 28% and arterial [HCO3-] by 7% without influencing duodenal HCO3- secretion. We suggest that the hypovolemia-induced inhibition of duodenal alkaline secretion is not caused by a decrease in blood and/or arterial [HCO3-]. Instead, other factors may be of importance, for example, neural effects on enteric secretomotor neurons or directly on the secreting epithelium.


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B. Johansson, M. Holm, S. Ewert, A. Casselbrant, A. Pettersson, and L. Fandriks
Angiotensin II type 2 receptor-mediated duodenal mucosal alkaline secretion in the rat
Am J Physiol Gastrointest Liver Physiol, June 1, 2001; 280(6): G1254 - G1260.
[Abstract] [Full Text] [PDF]


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