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AJP - Gastrointestinal and Liver Physiology, Vol 259, Issue 6 1031-G1036, Copyright © 1990 by American Physiological Society
ARTICLES |
H. C. Lin, J. E. Doty, T. J. Reedy and J. H. Meyer
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Previously, we reported that inhibition of gastric emptying by glucose or acids depends on the length of gut exposed to the inhibitor [Gastroenterology 95: A877, 1988; Am. J. Physiol. 256 (Gastrointest. Liver Physiol. 19): G404-G411, 1989]. In this study, we hypothesized that feedback control by fat may be similarly regulated. In dogs with chronic intestinal fistulas, we compared the intensity of intestinal feedback when different lengths of the small intestine were exposed to meals of 3, 9, or 27 mM sodium oleate. We found that 1) inhibition of liquid emptying was dose dependent, 2) intensity of negative feedback was dependent on both the concentration of the oleate and the length of gut exposed to fat, 3) full inhibitory effect was achieved with exposure of fat to 150 cm of gut, 4) inhibition from the distal one-half of gut was less potent than that generated from the proximal one-half of gut, and 5) on a molar basis oleate was 20 times as effective as glucose at inhibition of gastric emptying and that this difference was related to the slower rate of fat absorption.
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W.-M. Sun, S. Doran, K. L. Jones, E. Ooi, G. Boeckxstaens, G. S. Hebbard, T. Lingenfelser, J. E. Morley, J. Dent, and M. Horowitz Effects of nitroglycerin on liquid gastric emptying and antropyloroduodenal motility Am J Physiol Gastrointest Liver Physiol, November 1, 1998; 275(5): G1173 - G1178. [Abstract] [Full Text] [PDF]
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J. H. Meyer, M. Hlinka, A. Khatibi, H. E. Raybould, and P. Tso Role of small intestine in caloric compensations to oil premeals in rats Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1998; 275(4): R1320 - R1333. [Abstract] [Full Text] [PDF]
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E. Weber and H. J. Ehrlein Reserve capacities of the small intestine for absorption of energy Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1998; 275(1): R300 - R307. [Abstract] [Full Text] [PDF]
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J. M. Andrews, S. Doran, G. S. Hebbard, G. Rassias, W.-M. Sun, and M. Horowitz Effect of glucose supplementation on appetite and the pyloric motor response to intraduodenal glucose and lipid Am J Physiol Gastrointest Liver Physiol, April 1, 1998; 274(4): G645 - G652. [Abstract] [Full Text] [PDF]
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