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Am J Physiol Gastrointest Liver Physiol 260: G610-G614, 1991;
0193-1857/91 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 260, Issue 4 610-G614, Copyright © 1991 by American Physiological Society

ARTICLES

Circadian rhythms of acid and bicarbonate efflux in fasting rat stomach

K. R. Larsen, J. G. Moore and M. T. Dayton
Department of Medicine, Salt Lake Veterans Affairs Medical Center 84148.

One model of gastric ulcerogenesis implicates a disruption of complementary circadian rhythms between protective and destructive factors. The purpose of this study was to compare circadian rhythms in gastric production of H+ and HCO3- in fasted rats. Sprague-Dawley rats were acclimatized in sound-attenuating, light-proof chambers for 3 wk on a 12:12-h light-dark schedule. Eighteen-hour fasted rats were studied at each of eight sampling times. After anesthesia, the stomachs were cannulated and filled with test solution. Thirty-minute gastric samples were titrated for H+ or assayed for HCO3-. Cosinor analysis of the data showed significant (P less than 0.05) circadian rhythms for both H+ and HCO3-. Peak times were 22:45 HALO (hours after lights on) (4:45 A.M.) for H+ and 05:41 HALO (11:41 A.M.) for HCO3-. These data demonstrate that H+ and HCO3- secretion in the fasting rat gastric lumen follow circadian rhythms with different peak times. Theoretically, this may result in circadian rhythmicity of relative mucosal vulnerability to injury.


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