| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Gastrointestinal and Liver Physiology, Vol 261, Issue 3 553-G557, Copyright © 1991 by American Physiological Society
ARTICLES |
K. D. Thornbury, S. M. Ward, H. H. Dalziel, A. Carl, D. P. Westfall and K. M. Sanders
Department of Physiology, University of Nevada, School of Medicine, Reno 89557.
Previous evidence suggests that nonadrenergic, noncholinergic (NANC) inhibitory neurotransmission in visceral muscles may be mediated by nitric oxide (NO). We have demonstrated that NO and the NO carrier S-nitrosocysteine can mimic the hyperpolarization in colonic muscle caused by nerve stimulation. The finding that S-nitrosocysteine breaks down fast enough to cause inhibitory junction potential (IJP)-like hyperpolarizations suggests that NO could be stored as a nitrosothiol in secretory vesicles in nerve terminals. Oxyhemoglobin blocked hyperpolarization responses to NO and S-nitrosocysteine and NANC IJPs. These findings suggest that NO is a biologically active transmitter substance in NANC inhibitory neurotransmission. NO enhanced the open probability of Ca(2+)-activated K+ channels in isolated colonic muscle cells. These channels may mediate the hyperpolarization response to NANC neurotransmission in colonic muscles.
This article has been cited by other articles:
|
|
 |
|
  M. Kim and B. A. Perrino CaM kinase II activation and phospholamban phosphorylation by SNP in murine gastric antrum smooth muscles Am J Physiol Gastrointest Liver Physiol, April 1, 2007; 292(4): G1045 - G1054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kim, I. S. Han, S. D. Koh, and B. A. Perrino Roles of CaM kinase II and phospholamban in SNP-induced relaxation of murine gastric fundus smooth muscles Am J Physiol Cell Physiol, August 1, 2006; 291(2): C337 - C347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. El-Yazbi, W. J. Cho, G. Boddy, R. Schulz, and E. E. Daniel Impact of caveolin-1 knockout on NANC relaxation in circular muscles of the mouse small intestine compared with longitudinal muscles Am J Physiol Gastrointest Liver Physiol, February 1, 2006; 290(2): G394 - G403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ro, W. J. Hatton, S. D. Koh, and B. Horowitz Molecular properties of small-conductance Ca2+-activated K+ channels expressed in murine colonic smooth muscle Am J Physiol Gastrointest Liver Physiol, October 1, 2001; 281(4): G964 - G973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gonzalez and S. K. Sarna Neural regulation of in vitro giant contractions in the rat colon Am J Physiol Gastrointest Liver Physiol, July 1, 2001; 281(1): G275 - G282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-C. Kwon, H. Ozaki, and H. Karaki NO donor sodium nitroprusside inhibits excitation-contraction coupling in guinea pig taenia coli Am J Physiol Gastrointest Liver Physiol, December 1, 2000; 279(6): G1235 - G1241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Iida, Z. S. Katusic, and E. P. Wei Mechanisms of Cerebral Arterial Relaxations to Hydrogen Peroxide Editorial Comment Stroke, September 1, 2000; 31(9): 2224 - 2230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-Y. Koh and J. W. Jacklet Nitric Oxide Stimulates cGMP Production and Mimics Synaptic Responses in Metacerebral Neurons of Aplysia J. Neurosci., May 15, 1999; 19(10): 3818 - 3826. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Sandner, M. Kornfeld, X. Ruan, W. J. Arendshorst, and A. Kurtz Nitric Oxide/cAMP Interactions in the Control of Rat Renal Vascular Resistance Circ. Res., February 5, 1999; 84(2): 186 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Franck, M. Storr, A. Puschmann, V. Schusdziarra, and H.-D. Allescher Involvement of intracellular Ca2+ stores in inhibitory effects of NO donor SIN-1 and cGMP Am J Physiol Gastrointest Liver Physiol, July 1, 1998; 275(1): G159 - G168. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. KURIYAMA, K. KITAMURA, T. ITOH, and R. INOUE Physiological Features of Visceral Smooth Muscle Cells, With Special Reference to Receptors and Ion Channels Physiol Rev, July 1, 1998; 78(3): 811 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lu, B. Mazet, M. G. Sarr, and J. H. Szurszewski Effect of nitric oxide on calcium-activated potassium channels in colonic smooth muscle of rabbits Am J Physiol Gastrointest Liver Physiol, May 1, 1998; 274(5): G848 - G856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lu, X. Qian, I. Berezin, G. L. Telford, J. D. Huizinga, and S. K. Sarna Inflammation modulates in vitro colonic myoelectric and contractile activity and interstitial cells of Cajal Am J Physiol Gastrointest Liver Physiol, December 1, 1997; 273(6): G1233 - G1245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Koh, G. M. Dick, and K. M. Sanders Small-conductance Ca2+-dependent K+ channels activated by ATP in murine colonic smooth muscle Am J Physiol Cell Physiol, December 1, 1997; 273(6): C2010 - C2021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Wellman, A. D. Bonev, M. T. Nelson, and J. E. Brayden Gender Differences in Coronary Artery Diameter Involve Estrogen, Nitric Oxide, and Ca2+-Dependent K+ Channels Circ. Res., November 1, 1996; 79(5): 1024 - 1030. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
