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Am J Physiol Gastrointest Liver Physiol 262: G216-G222, 1992;
0193-1857/92 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 262, Issue 2 216-G222, Copyright © 1992 by American Physiological Society

ARTICLES

TRH analogue microinjected into specific medullary nuclei stimulates gastric serotonin secretion in rats

H. Yang, R. L. Stephens and Y. Tache
Veterans Administration Wadsworth Medical Center, Department of Medicine, Los Angeles, California.

Brain nuclei involved in vagal release of gastric serotonin (5-HT) were investigated in urethan-anesthetized rats acutely implanted with gastric cannula. Gastric secretions were collected every 10-15 min for 2 h, and measurement of serotonin 5-HT was performed by high-performance liquid chromatography (HPLC) with electrochemical detection and that of acid by titration. The stable thyrotropin-releasing hormone (TRH) analogue, RX 77368, microinjected into the dorsal vagal complex (DVC) (1.5-77 pmol/50 nl) induced a dose-related and long-lasting increase in gastric 5-HT and acid output. TRH (276 pmol) microinjected into the DVC also stimulated gastric 5-HT secretion. TRH action was abolished by vagotomy. RX 77368 (77 pmol) increased 5-HT release after microinjection into the raphe obscurus, raphe pallidus, and nucleus ambiguus, although the responses were significantly lower compared with that induced by DVC microinjection. No changes in gastric 5-HT release were observed when the peptide was microinjected into the lateral hypothalamus, hypoglossal, paramedian reticular, inferior olive, lateral paragigantocellular or spinal trigeminal nucleus. The potent gastric 5-HT release induced by TRH or TRH analogue into the DVC added to the presence of TRH receptors and TRH-LI nerve terminals in the DVC suggest a role of medullary TRH in the vagal regulation of gastric 5-HT release.


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