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Am J Physiol Gastrointest Liver Physiol 262: G308-G311, 1992;
0193-1857/92 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 262, Issue 2 308-G311, Copyright © 1992 by American Physiological Society

ARTICLES

EndothelinB receptor on guinea pig small intestinal smooth muscle cells

M. Yoshinaga, Y. Chijiiwa, T. Misawa, N. Harada and H. Nawata
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

We investigated the binding characteristics of the endothelin (ET) receptor and the mechanism by which ET induces contraction of longitudinal smooth muscle cells of the guinea pig small intestine by using vasoactive intestinal contractor (VIC), a mouse variant of ET-2. A functional receptor for VIC was found to exist on longitudinal smooth muscle cells. These cells showed a similar binding of and contractile response to ET-1, ET-2, and ET-3. Inhibitors of both intracellular and extracellular Ca2+ movement attenuated the VIC-induced contraction of longitudinal smooth muscle cells. These results suggest that smooth muscle cells of the guinea pig small intestine express the ETB receptor that primarily mediates the contractile effect on smooth muscle cells. In addition, ET-induced contraction depends on intracellular as well as extracellular Ca2+.


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C. E. King-VanVlack, J. D. Mewburn, and C. K. Chapler
Receptor-mediated vascular and metabolic actions of endothelin-1 in canine small intestine
Am J Physiol Gastrointest Liver Physiol, May 1, 1999; 276(5): G1131 - G1136.
[Abstract] [Full Text] [PDF]


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