| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Gastrointestinal and Liver Physiology, Vol 262, Issue 6 1041-G1046, Copyright © 1992 by American Physiological Society
ARTICLES |
M. G. Blennerhassett, P. Vignjevic, D. L. Vermillion and S. M. Collins
Intestinal Disease Research Unit, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada.
Inflammation of the rat jejunum with Trichinella spiralis causes altered smooth muscle contractility by day 6 postinfection (PI). We investigated the association of structural change in the smooth muscle layers with inflammation. By day 6 PI, smooth muscle area in cross sections of jejunum increased (P less than 0.05) in longitudinal (LM) and circular (CM) muscle layers. Nuclei counting in cross sections showed that cell number increased two- to threefold in CM and LM, and this increase was not reversed on day 23 PI. Estimation of cell size showed significant hypertrophy by day 6 PI in both muscle layers. [3H]thymidine autoradiography showed that the labeling index (LI) of jejunal LM and CM increased sharply on day 4 PI and peaked on day 6 PI (10- to 15-fold increase). The noninflamed ileum showed a smaller trophic response, with no significant change in area or nuclei number, the LI was increased only on day 6 PI in the ileal CM and was unchanged in LM. Thus extensive hyperplasia and hypertrophy of smooth muscle cells are associated with intestinal inflammation.
This article has been cited by other articles:
|
|
 |
|
  T. Ohama, M. Hori, E. Momotani, M. Elorza, W. T. Gerthoffer, and H. Ozaki IL-1beta inhibits intestinal smooth muscle proliferation in an organ culture system: involvement of COX-2 and iNOS induction in muscularis resident macrophages Am J Physiol Gastrointest Liver Physiol, May 1, 2007; 292(5): G1315 - G1322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ohama, M. Hori, E. Momotani, Y. Iwakura, F. Guo, H. Kishi, S. Kobayashi, and H. Ozaki Intestinal inflammation downregulates smooth muscle CPI-17 through induction of TNF-{alpha} and causes motility disorders Am J Physiol Gastrointest Liver Physiol, May 1, 2007; 292(5): G1429 - G1438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cheng, W. Cao, C. Fiocchi, J. Behar, P. Biancani, and K. M. Harnett Platelet-activating factor and prostaglandin E2 impair esophageal ACh release in experimental esophagitis Am J Physiol Gastrointest Liver Physiol, September 1, 2005; 289(3): G418 - G428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-Z. Shi and S. K. Sarna Transcriptional regulation of inflammatory mediators secreted by human colonic circular smooth muscle cells Am J Physiol Gastrointest Liver Physiol, August 1, 2005; 289(2): G274 - G284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Akiho, P. Lovato, Y. Deng, P. J. M. Ceponis, P. Blennerhassett, and S. M. Collins Interleukin-4- and -13-induced hypercontractility of human intestinal muscle cells-implication for motility changes in Crohn's disease Am J Physiol Gastrointest Liver Physiol, April 1, 2005; 288(4): G609 - G615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Diez-Tascon, O. M. Keane, T. Wilson, A. Zadissa, D. L. Hyndman, D. B. Baird, J. C. McEwan, and A. M. Crawford Microarray analysis of selection lines from outbred populations to identify genes involved with nematode parasite resistance in sheep Physiol Genomics, March 21, 2005; 21(1): 59 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Torrents, R. Torres, F. de Mora, and P. Vergara Antinerve Growth Factor Treatment Prevents Intestinal Dysmotility in Trichinella spiralis-Infected Rats J. Pharmacol. Exp. Ther., August 1, 2002; 302(2): 659 - 665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lourenssen, A. Jeromin, J. Roder, and M. G. Blennerhassett Intestinal inflammation modulates expression of the synaptic vesicle protein neuronal calcium sensor-1 Am J Physiol Gastrointest Liver Physiol, June 1, 2002; 282(6): G1097 - G1104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Akiho, P. Blennerhassett, Y. Deng, and S. M. Collins Role of IL-4, IL-13, and STAT6 in inflammation-induced hypercontractility of murine smooth muscle cells Am J Physiol Gastrointest Liver Physiol, February 1, 2002; 282(2): G226 - G232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. G. Moreels, J. G. De Man, J. J. Bogers, B. Y. De Winter, G. Vrolix, A. G. Herman, E. A. Van Marck, and P. A. Pelckmans Effect of Schistosoma mansoni-induced granulomatous inflammation on murine gastrointestinal motility Am J Physiol Gastrointest Liver Physiol, May 1, 2001; 280(5): G1030 - G1042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Blennerhassett and S. Lourenssen Neural regulation of intestinal smooth muscle growth in vitro Am J Physiol Gastrointest Liver Physiol, September 1, 2000; 279(3): G511 - G519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Torrents and P. Vergara In vivo changes in the intestinal reflexes and the response to CCK in the inflamed small intestine of the rat Am J Physiol Gastrointest Liver Physiol, September 1, 2000; 279(3): G543 - G551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Venkova, S. T. Dunn, A. M. Adesina, and B. G.-V. Meerveld Neuromuscular Dysfunction in the Jejunum and Colon of Human Leukocyte Antigen B27 Transgenic Rats J. Pharmacol. Exp. Ther., April 1, 2000; 293(1): 60 - 66. [Abstract] [Full Text]
|
|
|
|
|
|
K. Venkova, J. M. Palmer, and B. G.-V. Meerveld Nematode-Induced Jejunal Inflammation in the Ferret Causes Long-Term Changes in Excitatory Neuromuscular Responses J. Pharmacol. Exp. Ther., July 1, 1999; 290(1): 96 - 103. [Abstract] [Full Text]
|
|
|
|
|
|
I. Khan, F. M. Al-Awadi, and H. Abul Colitis-Induced Changes in the Expression of the Na+/H+ Exchanger Isoform NHE-1 J. Pharmacol. Exp. Ther., May 1, 1998; 285(2): 869 - 875. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
