AJP - Gastrointestinal and Liver Physiology, Vol 263, Issue 6 967-G972, Copyright © 1992 by American Physiological Society

ARTICLES

Characterization of H2 histamine receptor: linkage to both adenylate cyclase and [Ca2+]i signaling systems

J. Delvalle, L. Wang, I. Gantz and T. Yamada
Department of Internal Medicine, University of Michigan and Medical Center, Ann Arbor 48109.

We undertook these studies to examine the intracellular mechanisms of histamine action using a rat hepatoma-derived cell line that had been transfected to express the H2 histamine receptor cDNA. Transfected cells demonstrated increased adenosine 3',5'-cyclic monophosphate production, membrane inositol phospholipid turnover, and intracellular Ca2+ concentration ([Ca2+]i) in response to histamine. All of the effects could be inhibited with the H2 histamine receptor antagonist cimetidine, and the increased membrane inositol phospholipid turnover and [Ca2+]i were abolished by cholera toxin pretreatment of cells. These data support the notion that a single histamine H2 receptor can be linked to two stimulatory intracellular signaling systems.

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