AJP - GI AJP: Advances in Physiology Education
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 264: G994-G1000, 1993;
0193-1857/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lugea, A.
Right arrow Articles by Malagelada, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lugea, A.
Right arrow Articles by Malagelada, J. R.

AJP - Gastrointestinal and Liver Physiology, Vol 264, Issue 5 994-1000, Copyright © 1993 by American Physiological Society

ARTICLES

Adaptive cytoprotection of the rat duodenum is not dependent on nitric oxide-induced changes in blood flow

A. Lugea, A. Salas, F. Guarner and J. R. Malagelada
Digestive System Research Unit, Hospital General Vall d'Hebron, Autonomous University of Barcelona, Spain.

Mild irritation of the rat duodenum enhances mucosal resistance to acid via a prostaglandin-mediated mechanism. Prostaglandins increase mucosal blood flow, but it is not known whether such changes in blood flow significantly contribute to adaptive cytoprotection. We induced blood flow changes by manipulating the arginine-nitric oxide pathway, which is independent from prostaglandin synthesis, and determined the resulting effects on the cytoprotective response. In anesthetized rats, we tested the effects of intraduodenal infusion of mild acid on duodenal blood flow and on the prevention of mucosal damage by subsequent strong acid in control, indomethacin-pretreated, and NG-nitro-L-arginine-pretreated rats (NG-nitro-L-arginine inhibits the nitric oxide synthase). Additional experiments tested the effects of the prostaglandin analogue 16,16-dimethyl-prostaglandin (PG) E2 or sodium nitroprusside (nitric oxide donor) on duodenal blood flow and on mucosal protection against acid. Exposure of the duodenal mucosa to mild acid increased duodenal blood flow and mucosal resistance to acid. Instillation of 16,16-dimethyl-PGE2 also increased blood flow and mucosal resistance to acid. However, sodium nitroprusside increased blood flow without increasing mucosal resistance to acid, and NG-nitro-L-arginine inhibited the change in blood flow induced by acid while preserving the adaptive cytoprotection phenomenon intact. In conclusion, adaptive cytoprotection of the duodenal mucosa appears to be independent of changes in blood flow.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
Y. Akiba, O. Furukawa, P. H. Guth, E. Engel, I. Nastaskin, and J. D. Kaunitz
Acute adaptive cellular base uptake in rat duodenal epithelium
Am J Physiol Gastrointest Liver Physiol, June 1, 2001; 280(6): G1083 - G1092.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
E. R. Kokoska, G. S. Smith, A. B. Wolff, Y. Deshpande, C. L. Rieckenberg, A. Banan, and T. A. Miller
Role of calcium in adaptive cytoprotection and cell injury induced by deoxycholate in human gastric cells
Am J Physiol Gastrointest Liver Physiol, August 1, 1998; 275(2): G322 - G330.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online