AJP - Gastrointestinal and Liver Physiology, Vol 265, Issue 1 113-G117, Copyright © 1993 by American Physiological Society
Neurotensin and oxyntomodulin-(30-37) potentiate PYY regulation of gastric acid and somatostatin secretions
A. Bado, D. Cloarec, L. Moizo, J. P. Laigneau, D. Bataille and M. J. Lewin
Institut National de la Sante et de la Recherche Medicale Unite de Gastroenterologie U10, Hopital Bichat, Paris, France.
The present study was designed to investigate, in cats provided with both a
gastric fistula and a denervated fundic Heidenhain pouch, the effect of
peptide YY (PYY) on pentagastrin-stimulated gastric acid and somatostatin
secretions and to determine whether neurotensin (NT) and the COOH-terminal
octapeptide of oxyntomodulin [Oxm-(30-37)] would modify these secretions.
Intravenous infusion of PYY (0.1 nmol.kg-1.h-1), NT (15 nmol.kg-1.h-1), or
Oxm-(30-37) (60 nmol.kg-1.h-1) did not affect basal acid secretion.
However, they significantly inhibited pentagastrin-stimulated gastric acid
output up to 50% (P < 0.01) in the main stomach. Furthermore, they
significantly increased gastric somatostatin release by +750, +1,700, and
+600% over basal level (P < 0.01) for (in nmol.kg-1.h-1) 0.1 PYY, 15 NT,
and 60 Oxm-(30-37), respectively. On the other hand, the effects of 0.1
nmol.kg-1.h-1 PYY were potentiated by subthreshold doses of NT (5
nmol.kg-1.h-1) or Oxm-(30-37) (15 nmol.kg-1.h-1). These findings suggest
that there could be a cooperation between the three peptides in the
intestinal regulation of gastric secretions.
