AJP - GI Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 265: G1064-G1070, 1993;
0193-1857/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goldhill, J. M.
Right arrow Articles by Percy, W. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goldhill, J. M.
Right arrow Articles by Percy, W. H.

AJP - Gastrointestinal and Liver Physiology, Vol 265, Issue 6 1064-G1070, Copyright © 1993 by American Physiological Society

ARTICLES

A novel in vitro technique to study extrinsic neural control of rabbit colonic muscle and epithelial function

J. M. Goldhill and W. H. Percy
Division of Gastroenterology, Winthrop-University Hospital, Mineola 11501.

A novel in vitro technique capable of simultaneously measuring distal colonic epithelial potential difference and muscle contraction is described. Under basal conditions, oscillations in both muscle tone and potential difference were observed. Pelvic nerve stimulation was shown to evoke strong "duration" contractile responses in both the longitudinal and circular muscle layers. Additionally, tonic changes in potential difference extending beyond the train of stimuli were observed, suggesting for the first time that colonic ion transport may be influenced by the pelvic nerves. However, it was unclear whether these were direct effects or indirect actions resulting from muscle contractions causing mechanical stimulation of nerves of the submucosal plexus. Lumbar colonic nerve stimulation inhibited spontaneous contractile activity and reduced basal tone in both muscle layers. However, there was no consistent effect of sympathetic nerve stimulation on transepithelial potential difference. Each of the muscle and epithelial effects of sympathetic nerve stimulation was mimicked by exogenous norepinephrine. Based on these data, it is concluded that colonic function is strongly influenced by the extrinsic innervation. Furthermore, relatively long-term modulation of epithelial function can be achieved by short bursts of pelvic nerve activity.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
W. H. Percy, T. H. Fromm, and C. E. Wangsness
Muscularis mucosae contraction evokes colonic secretion via prostaglandin synthesis and nerve stimulation
Am J Physiol Gastrointest Liver Physiol, February 1, 2003; 284(2): G213 - G220.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
W. H. Percy, J. T. Brunz, R. E. Burgers, T. H. Fromm, C. L. Merkwan, and J. van Dis
Interrelationship between colonic muscularis mucosae activity and changes in transmucosal potential difference
Am J Physiol Gastrointest Liver Physiol, August 1, 2001; 281(2): G479 - G489.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online