| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Gastrointestinal and Liver Physiology, Vol 267, Issue 5 794-G799, Copyright © 1994 by American Physiological Society
ARTICLES |
P. R. Saunders, U. Kosecka, D. M. McKay and M. H. Perdue
Department of Pathology, McMaster University, Hamilton, Ontario, Canada.
Wistar-Kyoto rats were subjected to 4 h restraint stress (RS) or cold restraint stress (CRS), and jejunal tissues were examined in Ussing chambers for alterations in transport functions compared with tissues from unstressed control rats. The baseline short-circuit current (Isc) was significantly elevated in tissues from RS (approximately 50%) and CRS (100%). Substitution of Cl- eliminated the abnormality, suggesting that stress stimulates Cl- secretion. Electrical transmural stimulation of enteric nerves caused a transient increase in Isc in all tissues. The magnitude of this response was significantly less in tissues from CRS than from control rats; however, the ability of the epithelium to secrete in response to exogenous stimulation with bethanechol or vasoactive intestinal polypeptide was unimpaired, implicating a neural change. Tissue conductance was higher in jejunum from RS and CRS rats than from controls. Increased intestinal epithelial permeability in stressed rats was confirmed by significantly greater fluxes of the inert radiolabeled probes, [3H]mannitol and 51Cr-labeled EDTA. No structural changes were observed. We conclude that acute stressors have profound effects on intestinal epithelial physiology, stimulating ion secretion and reducing barrier function.
This article has been cited by other articles:
|
|
 |
|
  K. M. Burkholder, K. L. Thompson, M. E. Einstein, T. J. Applegate, and J. A. Patterson Influence of Stressors on Normal Intestinal Microbiota, Intestinal Morphology, and Susceptibility to Salmonella Enteritidis Colonization in Broilers Poult. Sci., September 1, 2008; 87(9): 1734 - 1741. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Mazzon and S. Cuzzocrea Role of TNF-{alpha} in ileum tight junction alteration in mouse model of restraint stress Am J Physiol Gastrointest Liver Physiol, May 1, 2008; 294(5): G1268 - G1280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Sun, H. Yang, K. Nose, S. Nose, E. Q. Haxhija, H. Koga, Y. Feng, and D. H. Teitelbaum Decline in intestinal mucosal IL-10 expression and decreased intestinal barrier function in a mouse model of total parenteral nutrition Am J Physiol Gastrointest Liver Physiol, January 1, 2008; 294(1): G139 - G147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Gareau, J. Jury, and M. H. Perdue Neonatal maternal separation of rat pups results in abnormal cholinergic regulation of epithelial permeability Am J Physiol Gastrointest Liver Physiol, July 1, 2007; 293(1): G198 - G203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Nylander, L. Pihl, and M. Perry Hypotonicity-induced increases in duodenal mucosal permeability facilitates adjustment of luminal osmolality Am J Physiol Gastrointest Liver Physiol, July 7, 2003; 285(2): G360 - G370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Soderholm, D. A. Yates, M. G. Gareau, P.-C. Yang, G. MacQueen, and M. H. Perdue Neonatal maternal separation predisposes adult rats to colonic barrier dysfunction in response to mild stress Am J Physiol Gastrointest Liver Physiol, December 1, 2002; 283(6): G1257 - G1263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E Mazzon, G C Sturniolo, D Puzzolo, N Frisina, and W Fries Effect of stress on the paracellular barrier in the rat ileum Gut, October 1, 2002; 51(4): 507 - 513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. d. Fleming, B. W. Starnes, J. G. Kiang, A. Stojadinovic, G. C. Tsokos, and T. Shea-Donohue Heat stress protection against mesenteric I/R-induced alterations in intestinal mucosa in rats J Appl Physiol, June 1, 2002; 92(6): 2600 - 2607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Nylander, A. Hallgren, and M. Sababi COX inhibition excites enteric nerves that affect motility, alkaline secretion, and permeability in rat duodenum Am J Physiol Gastrointest Liver Physiol, November 1, 2001; 281(5): G1169 - G1178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Yates, J. Santos, J. D. Soderholm, and M. H. Perdue Adaptation of stress-induced mucosal pathophysiology in rat colon involves opioid pathways Am J Physiol Gastrointest Liver Physiol, July 1, 2001; 281(1): G124 - G128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Soderholm and M. H. Perdue Stress and the Gastrointestinal Tract: II. Stress and intestinal barrier function Am J Physiol Gastrointest Liver Physiol, January 1, 2001; 280(1): G7 - G13. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Santos and M H Perdue Stress and neuroimmune regulation of gut mucosal function Gut, December 1, 2000; 47(90004): iv49 - 51. [Full Text] [PDF]
|
|
|
|
|
|
M A Benjamin, D M McKay, P-C Yang, H Cameron, and M H Perdue Glucagon-like peptide-2 enhances intestinal epithelial barrier function of both transcellular and paracellular pathways in the mouse Gut, July 1, 2000; 47(1): 112 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Santos, M. Benjamin, P.-C. Yang, T. Prior, and M. H. Perdue Chronic stress impairs rat growth and jejunal epithelial barrier function: role of mast cells Am J Physiol Gastrointest Liver Physiol, June 1, 2000; 278(6): G847 - G854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Santos, P. R. Saunders, N. P. M. Hanssen, P.-C. Yang, D. Yates, J. A. Groot, and M. H. Perdue Corticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat Am J Physiol Gastrointest Liver Physiol, August 1, 1999; 277(2): G391 - G399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Perdue III. The mucosal antigen barrier: cross talk with mucosal cytokines Am J Physiol Gastrointest Liver Physiol, July 1, 1999; 277(1): G1 - G5. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J M Mariadason, A Catto-Smith, and P R Gibson Modulation of distal colonic epithelial barrier function by dietary fibre in normal rats Gut, March 1, 1999; 44(3): 394 - 399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Kiliaan, P. R. Saunders, P. B. Bijlsma, M. C. Berin, J. A. Taminiau, J. A. Groot, and M. H. Perdue Stress stimulates transepithelial macromolecular uptake in rat jejunum Am J Physiol Gastrointest Liver Physiol, November 1, 1998; 275(5): G1037 - G1044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zareie, D. M. McKay, G. G. Kovarik, and M. H. Perdue Monocyte/macrophages evoke epithelial dysfunction: indirect role of tumor necrosis factor-alpha Am J Physiol Cell Physiol, October 1, 1998; 275(4): C932 - C939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M R Uhing Effect of sodium ion coupled nutrient transport on intestinal permeability in chronically catheterised rats Gut, July 1, 1998; 43(1): 22 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. McKay, M. A. Benjamin, and J. Lu CD4+ T cells mediate superantigen-induced abnormalities in murine jejunal ion transport Am J Physiol Gastrointest Liver Physiol, July 1, 1998; 275(1): G29 - G38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Castagliuolo, B. K. Wershil, K. Karalis, A. Pasha, S. T. Nikulasson, and C. Pothoulakis Colonic mucin release in response to immobilization stress is mast cell dependent Am J Physiol Gastrointest Liver Physiol, June 1, 1998; 274(6): G1094 - G1100. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
