AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 267: G908-G913, 1994;
0193-1857/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Houglum, K.
Right arrow Articles by Chojkier, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Houglum, K.
Right arrow Articles by Chojkier, M.

AJP - Gastrointestinal and Liver Physiology, Vol 267, Issue 5 908-G913, Copyright © 1994 by American Physiological Society

ARTICLES

TGF-beta and collagen-alpha 1 (I) gene expression are increased in hepatic acinar zone 1 of rats with iron overload

K. Houglum, P. Bedossa and M. Chojkier
Department of Medicine, Veterans Affairs Medical Center, San Diego, California.

We have shown that lipid peroxidation stimulates collagen-alpha 1 (I) gene transcription in cultured cells. Because iron is a transitional metal known to induce lipid peroxidation, we investigated whether hepatic lipid peroxidation modulates collagen gene expression in iron-overloaded rats. In this animal model of hemochromatosis, we show colocalization with iron in the hepatic acinar zone 1 of both lipid peroxidation and increased collagen-alpha 1 (I) transcripts, using immunohistochemistry for malondialdehyde-protein adducts and in situ hybridization, respectively. Iron overload stimulated the expression of the cytokine transforming growth factor-beta (TGF-beta) in acinar zone 1, in spite of the minor degree of hepatocellular necrosis and inflammation. The formation of reactive aldehydes and TGF-beta, both inducers of collagen gene expression, may play a role in the stimulation of hepatic collagen production in iron overload. These mechanisms could be a link between iron overload and fibrosis in genetic hemochromatosis.


This article has been cited by other articles:


Home page
 J. Nutr.Home page
S. L. Foster, S. H. Richardson, and M. L. Failla
Elevated Iron Status Increases Bacterial Invasion and Survival and Alters Cytokine/Chemokine mRNA Expression in Caco-2 Human Intestinal Cells
J. Nutr., May 1, 2001; 131(5): 1452 - 1458.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. Chojkier, K. Houglum, K. S. Lee, and M. Buck
Long- and short-term D-alpha -tocopherol supplementation inhibits liver collagen alpha 1(I) gene expression
Am J Physiol Gastrointest Liver Physiol, December 1, 1998; 275(6): G1480 - G1485.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Pigeon, G. Ilyin, B. Courselaud, P. Leroyer, B. Turlin, P. Brissot, and O. Loreal
A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload
J. Biol. Chem., March 9, 2001; 276(11): 7811 - 7819.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online