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Am J Physiol Gastrointest Liver Physiol 267: G1035-G1040, 1994;
0193-1857/94 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 267, Issue 6 1035-G1040, Copyright © 1994 by American Physiological Society

ARTICLES

Glutamine-enriched enteral diet increases splanchnic blood flow in the rat

A. P. Houdijk, P. A. Van Leeuwen, M. A. Boermeester, T. Van Lambalgen, T. Teerlink, E. L. Flinkerbusch, H. P. Sauerwein and R. I. Wesdorp
Department of Surgery and Clinical Chemistry, Free University Hospital, Amsterdam, The Netherlands.

The hemodynamic consequences of glutamine (Gln)-enriched nutrition have not been investigated. This study investigates the effects of a Gln-enriched enteral diet on organ blood flows and systemic hemodynamics. Male Fischer 344 rats (n = 24) were randomized to a group that received a 12.5% (wt/wt) Gln-enriched enteral diet or an isonitrogenous isocaloric control diet for 14 days. Blood flow measurements were performed at day 16 using 46Sc-labeled microspheres. In the Gln-enriched group, higher organ blood flows were measured in the stomach (51%), the pancreas (35%), small intestine (32%), and colon (55%), compared with controls. No differences were found in systemic hemodynamic parameters between the control and Gln-supplemented groups. A possible role for nitric oxide in this splanchnic vasodilation was investigated. Daily urinary nitrate excretion was measured during the study but showed no significant differences between the control and Gln-fed animals. No differences were found in plasma levels of the vasodilating hormone glucagon between the groups. These results show that a Gln-enriched enteral diet increased splanchnic blood flow, which was not mediated by pancreatic glucagon or increased nitric oxide production as determined by urinary nitrate excretion.


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