| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Gastrointestinal and Liver Physiology, Vol 268, Issue 4 622-G630, Copyright © 1995 by American Physiological Society
ARTICLES |
C. J. Bell, D. G. Gall and J. L. Wallace
Gastrointestinal Research Group, Faculty of Medicine, University of Calgary, Alberta, Canada.
The time course of disturbances of distal colonic electrolyte transport during experimental colitis in rats was compared with changes in the severity of inflammation and epithelial disruption. Colitis was induced by intracolonic administration of trinitrobenzenesulfonic acid (TNBS). At time points from 1 day to 8 wk thereafter, Na+ and Cl- transport was studied under short-circuited conditions in Ussing chambers, three indexes of tissue inflammation were measured, and histology was performed. Net absorption of Na+ and Cl- was abolished at 1 and 4 days after induction of colitis, but recovered to control levels by 1 wk. All unidirectional electrolyte fluxes were elevated at 1 day and fell significantly, generally to control levels, by 4 days. The indexes of inflammation, tissue myeloperoxidase, and synthetic capacities for prostaglandin E2 and leukotriene B4 were all significantly elevated from 1 day to 2 wk post-TNBS. At 1 and 4 days, there was widespread epithelial necrosis, and reepithelialization was consistently seen by 2 wk. In additional studies, 2 wk post-TNBS, the short-circuit current response to 3-isobutyl-1-methylxanthine was reduced compared with controls. These data suggest that abolition of electrolyte absorption early in this experimental colitis was largely attributable to epithelial damage. Despite demonstrable tissue inflammation 2 wk post-TNBS, basal electrolyte transport was not impaired, while the colitic epithelium was hyporesponsive to a Cl- secretagogue. The data also suggest that gross barrier function was restored prior to reepithelialization.
This article has been cited by other articles:
|
|
 |
|
  J. R O'Hara, A. E Lomax, G. M Mawe, and K. A Sharkey Ileitis alters neuronal and enteroendocrine signalling in guinea pig distal colon Gut, February 1, 2007; 56(2): 186 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Spencer, N. P. Hyland, K. A. Sharkey, and Q. J. Pittman Neonatal immune challenge exacerbates experimental colitis in adult rats: potential role for TNF-{alpha} Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R308 - R315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Walker, H. B. Jijon, T. Churchill, M. Kulka, and K. L. Madsen Activation of AMP-activated protein kinase reduces cAMP-mediated epithelial chloride secretion Am J Physiol Gastrointest Liver Physiol, November 1, 2003; 285(5): G850 - G860. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Rodriguez-Cabezas, J. Galvez, M. D. Lorente, A. Concha, D. Camuesco, S. Azzouz, A. Osuna, L. Redondo, and A. Zarzuelo Dietary Fiber Down-Regulates Colonic Tumor Necrosis Factor {alpha} and Nitric Oxide Production in Trinitrobenzenesulfonic Acid-Induced Colitic Rats J. Nutr., November 1, 2002; 132(11): 3263 - 3271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lohi, S. Makela, K. Pulkkinen, P. Hoglund, M.-L. Karjalainen-Lindsberg, P. Puolakkainen, and J. Kere Upregulation of CFTR expression but not SLC26A3 and SLC9A3 in ulcerative colitis Am J Physiol Gastrointest Liver Physiol, September 1, 2002; 283(3): G567 - G575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. B. Renes, M. Verburg, D. J. P. M. Van Nispen, H. A. Buller, J. Dekker, and A. W. C. Einerhand Distinct epithelial responses in experimental colitis: implications for ion uptake and mucosal protection Am J Physiol Gastrointest Liver Physiol, July 1, 2002; 283(1): G169 - G179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Miceli, G. P. Morris, W. K. MacNaughton, and S. Vanner Alterations in capsaicin-evoked electrolyte transport during the evolution of guinea pig TNBS ileitis Am J Physiol Gastrointest Liver Physiol, June 1, 2002; 282(6): G972 - G980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J C J Oprins, C van der Burg, H P Meijer, T Munnik, and J A Groot Tumour necrosis factor {alpha} potentiates ion secretion induced by histamine in a human intestinal epithelial cell line and in mouse colon: involvement of the phospholipase D pathway Gut, March 1, 2002; 50(3): 314 - 321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Asfaha, W. K. MacNaughton, C. B. Appleyard, K. Chadee, and J. L. Wallace Persistent epithelial dysfunction and bacterial translocation after resolution of intestinal inflammation Am J Physiol Gastrointest Liver Physiol, September 1, 2001; 281(3): G635 - G644. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Rocha, M. W. Musch, L. Lishanskiy, C. Bookstein, K. Sugi, Y. Xie, and E. B. Chang IFN-{gamma} downregulates expression of Na+/H+ exchangers NHE2 and NHE3 in rat intestine and human Caco-2/bbe cells Am J Physiol Cell Physiol, May 1, 2001; 280(5): C1224 - C1232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. ESFANDYARI, W. K. MACNAUGHTON, R. QUIRION, S. ST. PIERRE, J.-L. JUNIEN, and K. A. SHARKEY A novel receptor for calcitonin gene-related peptide (CGRP) mediates secretion in the rat colon: implications for secretory function in colitis FASEB J, July 1, 2000; 14(10): 1439 - 1446. [Abstract] [Full Text]
|
|
|
|
|
|
C J Bell, E J Elliott, J L Wallace, D M Redmond, J Payne, Z Li, and E V O'Loughlin Do eicosanoids cause colonic dysfunction in experimental E coli 0157:H7 (EHEC) infection? Gut, June 1, 2000; 46(6): 806 - 812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-Z. Shi and S. K. Sarna Impairment of Ca2+ mobilization in circular muscle cells of the inflamed colon Am J Physiol Gastrointest Liver Physiol, February 1, 2000; 278(2): G234 - G242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-Z. Shi and S. K. Sarna Differential inflammatory modulation of canine ileal longitudinal and circular muscle cells Am J Physiol Gastrointest Liver Physiol, August 1, 1999; 277(2): G341 - G350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Hathaway, C. B. Appleyard, W. H. Percy, and J. L. Williams Experimental colitis increases blood-brain barrier permeability in rabbits Am J Physiol Gastrointest Liver Physiol, May 1, 1999; 276(5): G1174 - G1180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Brown, Q. Chang, B. D. Soper, and B. L. Tepperman Protein kinase C mediates experimental colitis in the rat Am J Physiol Gastrointest Liver Physiol, March 1, 1999; 276(3): G583 - G590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Asfaha, C. J. Bell, J. L. Wallace, and W. K. MacNaughton Prolonged colonic epithelial hyporesponsiveness after colitis: role of inducible nitric oxide synthase Am J Physiol Gastrointest Liver Physiol, March 1, 1999; 276(3): G703 - G710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Radojevic, D. M. McKay, M. Merger, B. A. Vallance, S. M. Collins, and K. Croitoru Characterization of enteric functional changes evoked by in vivo anti-CD3 T cell activation Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1999; 276(3): R715 - R723. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. D. SCHULTZ, A. K. SINGH, D. C. DEVOR, and R. J. BRIDGES Pharmacology of CFTR Chloride Channel Activity Physiol Rev, January 1, 1999; 79(1): 109 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. K. MacNaughton, S. S. Lowe, and K. Cushing Role of nitric oxide in inflammation-induced suppression of secretion in a mouse model of acute colitis Am J Physiol Gastrointest Liver Physiol, December 1, 1998; 275(6): G1353 - G1360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. McKay, M. A. Benjamin, and J. Lu CD4+ T cells mediate superantigen-induced abnormalities in murine jejunal ion transport Am J Physiol Gastrointest Liver Physiol, July 1, 1998; 275(1): G29 - G38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. S. Myers, J. S. Martin, D. T. Dempsey, H. P. Parkman, R. M. Thomas, and J. P. Ryan Acute experimental colitis decreases colonic circular smooth muscle contractility in rats Am J Physiol Gastrointest Liver Physiol, October 1, 1997; 273(4): G928 - G936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Morel, I. Dublineau, F. Lebrun, and N. M. Griffiths Alterations of the VIP-stimulated cAMP pathway in rat distal colon after abdominal irradiation Am J Physiol Gastrointest Liver Physiol, May 1, 2002; 282(5): G835 - G843. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
