AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 268: G895-G899, 1995;
0193-1857/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Saperas, E.
Right arrow Articles by Malagelada, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Saperas, E.
Right arrow Articles by Malagelada, J. R.

AJP - Gastrointestinal and Liver Physiology, Vol 268, Issue 6 895-G899, Copyright © 1995 by American Physiological Society

ARTICLES

Central vagal activation by an analogue of TRH stimulates gastric nitric oxide release in rats

E. Saperas, M. Mourelle, J. Santos, S. Moncada and J. R. Malagelada
Digestive System Research Unit, Hospital General Vall d'Hebron, Autonomous University of Barcelona, Spain.

In the stomach nitric oxide (NO) appears to be involved in vagally induced cholinergic vasodilation and nonadrenergic, noncholinergic relaxation of the fundus. We investigated whether central vagal activation by intracisternal injection of a thyrotropin-releasing hormone (TRH) analogue stimulates gastric NO release in anesthetized rats. To quantitate gastric NO production, the luminal release of NO breakdown products, nitrite (NO2-) and nitrate (NO3-), were measured by the Griess method. Intracisternal injection of RX-77368 (30-300 ng) dose dependently stimulated gastric NO2- and NO3- release (P < 0.05) along with a significant acid secretory response (P < 0.05). The specific inhibitor of NO synthesis, NG-nitro-L-arginine methyl ester (10 mg/kg ip), completely blocked gastric luminal NO2- and NO3- release without affecting the acid secretory response to the highest dose of RX-77368. Either bilateral cervical vagotomy, hexamethonium (15 mg/kg ip), or atropine (1 mg/kg ip) abolished both gastric luminal release of NO-derived metabolites and the acid secretory responses to RX-77368. These results indicate that intracisternal injection of RX-77368 stimulates gastric release of NO through vagal nicotinic pathways and peripheral activation of muscarinic receptors. These findings provide evidence for central nervous system regulation of NO-mediated functions in the rat stomach through TRH-sensitive vagal pathways.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Premaratne, C. Xue, J. M. McCarty, M. Zaki, R. W. McCuen, R. A. Johns, W. Schepp, B. Neu, R. Lippman, P. D. Melone, et al.
Neuronal nitric oxide synthase: expression in rat parietal cells
Am J Physiol Gastrointest Liver Physiol, February 1, 2001; 280(2): G308 - G313.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
H. Kaneko, J. Kaunitz, and Y. Tache
Vagal mechanisms underlying gastric protection induced by chemical activation of raphe pallidus in rats
Am J Physiol Gastrointest Liver Physiol, November 1, 1998; 275(5): G1056 - G1062.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
K. Takada, K. Yamashita, Y. Sakurai-Yamashita, K. Shigematsu, Y. Hamada, K. Hioki, and K. Taniyama
Participation of Nitric Oxide in the Mucosal Injury of Rat Intestine Induced by Ischemia-Reperfusion
J. Pharmacol. Exp. Ther., October 1, 1998; 287(1): 403 - 407.
[Abstract] [Full Text]

Home page
 J. Pharmacol. Exp. Ther.Home page
K. Hosoda, T. Takahashi, M. A. Fujino, and C. Owyang
Inhibitory Effects of Nitric Oxide Donors on Nitric Oxide Synthesis in Rat Gastric Myenteric Plexus
J. Pharmacol. Exp. Ther., September 1, 1998; 286(3): 1222 - 1230.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Kaneko, T. Mitsuma, H. Nagai, S. Mori, T. Iyo, K. Kusugami, and Y. Tache
Central action of adrenomedullin to prevent ethanolinduced gastric injury through vagal pathways in rats
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1998; 274(6): R1783 - R1788.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. Tamori, M. Yoneda, K. Nakamura, and I. Makino
Effect of intracisternal thyrotropin-releasing hormone on hepatic blood flow in rats
Am J Physiol Gastrointest Liver Physiol, February 1, 1998; 274(2): G277 - G282.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. Kiraly, G. Suto, P. H. Guth, and Y. Tache
Peripheral mediators involved in gastric hyperemia to vagal activation by central TRH analog in rats
Am J Physiol Gastrointest Liver Physiol, January 1, 1998; 274(1): G170 - G177.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. Fragner, O. Presset, N. Bernad, J. Martinez, C. Roze, and S. Aratan-Spire
A new biological contribution of cyclo(His-Pro) to the peripheral inhibition of pancreatic secretion
Am J Physiol Endocrinol Metab, December 1, 1997; 273(6): E1127 - E1132.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. Kato, T. Hirata, M. Kitamura, and K. Takeuchi
Gastric Hyperemic Response During Vagally Mediated Acid Secretion by TRH Analog in Rats
J. Pharmacol. Exp. Ther., September 1, 1997; 282(3): 1351 - 1357.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online