AJP - GI AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 269: G458-G464, 1995;
0193-1857/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shiotani, A.
Right arrow Articles by Merchant, J. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shiotani, A.
Right arrow Articles by Merchant, J. L.

AJP - Gastrointestinal and Liver Physiology, Vol 269, Issue 3 458-G464, Copyright © 1995 by American Physiological Society

ARTICLES

cAMP regulates gastrin gene expression

A. Shiotani and J. L. Merchant
Howard Hughes Medical Institute Research Laboratories, University of Michigan Medical Center, Ann Arbor 48109-0650, USA.

Gastrin is one of the most potent regulators of acid secretion and gastrointestinal cell growth. A variety of signals regulate gastrin release from the antral G cell. However, whether these secretagogues also stimulate gastrin gene expression has not been established. Dramatic increases in gastrin gene expression occur in the stomach after birth and in response to chronic achlorhydria. Moreover, gastrin gene expression in malignant islet cell tumors (gastrinomas) appears to represent reactivation of the fetal pattern of expression in the pancreas. Thus differential expression of the gastrin gene is a reflection of differences in transcriptional control. Since various luminal and humoral factors stimulate the production of cAMP and gastrin secretion in both gastrinoma and antral G cells, we studied the effect of cAMP on gastrin gene expression. Using stable and transient transformants of a pituitary cell line containing the human gastrin gene, we found that cAMP stimulates a three-fold increase in gastrin mRNA levels and that the response maps to elements located between -148 and -40 base pairs upstream from the cap site. Collectively, these studies link an important regulator of gastrin secretion to regulation of gastrin gene expression.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
W. Wang, C. Li, T.-H. Kwon, M. A. Knepper, J. Frokiar, and S. Nielsen
AQP3, p-AQP2, and AQP2 expression is reduced in polyuric rats with hypercalcemia: prevention by cAMP-PDE inhibitors
Am J Physiol Renal Physiol, December 1, 2002; 283(6): F1313 - F1325.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-C. Gevrey, M. Cordier-Bussat, E. Nemoz-Gaillard, J.-A. Chayvialle, and J. Abello
Co-requirement of Cyclic AMP- and Calcium-dependent Protein Kinases for Transcriptional Activation of Cholecystokinin Gene by Protein Hydrolysates
J. Biol. Chem., June 14, 2002; 277(25): 22407 - 22413.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
T. Suzuki, E. Grand, C. Bowman, J. L. Merchant, A. Todisco, L. Wang, and J. Del Valle
TNF-alpha and interleukin 1 activate gastrin gene expression via MAPK- and PKC-dependent mechanisms
Am J Physiol Gastrointest Liver Physiol, December 1, 2001; 281(6): G1405 - G1412.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online