AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 269: G737-G744, 1995;
0193-1857/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gronbech, J. E.
Right arrow Articles by Lacy, E. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gronbech, J. E.
Right arrow Articles by Lacy, E. R.

AJP - Gastrointestinal and Liver Physiology, Vol 269, Issue 5 737-G744, Copyright © 1995 by American Physiological Society

ARTICLES

Role of gastric blood flow in impaired defense and repair of aged rat stomachs

J. E. Gronbech and E. R. Lacy
Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston 29425, USA.

To study impaired gastric mucosal tolerance against noxious agents in aged rats, possible factors underlying this observation were compared in anesthetized Fisher 344 young and aged rats. The gastric mucosa was damaged by in situ exposure to 80% ethanol for 30-45 s and by 1 M NaCl for 10 min followed by saline (pH = 1.0) for 60 min in chambered stomachs. The lesion area was significantly larger and epithelial restitution was significantly slower in aged than in young rats after both types of injury. Changes in gastric blood flow were monitored by laser-Doppler velocimetry. Young, but not aged, rats showed a marked increase in gastric blood flow in response to 1 M NaCl, acid challenge, and 640 microM capsaicin for 60 min. Young rats showed a higher density of calcitonin gene-related peptide (CGRP)-staining nerve fibers around submucosal blood vessels and higher mucosal release of prostaglandin E2 and leukotriene C4 than did aged rats. These data suggest that impaired mucosal defense and reduced restitution in aged rats is related to lack of hyperemic response caused by mucosal injury and H+ back-diffusion, which is probably due to decreased density of CGRP-staining nerve fibers and prostaglandin biosynthetic capacity in the mucosa.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
O. T. Starodub, E. S. Demitrack, H. K. Baumgartner, and M. H. Montrose
Disruption of the Cox-1 gene slows repair of microscopic lesions in the mouse gastric epithelium
Am J Physiol Cell Physiol, January 1, 2008; 294(1): C223 - C232.
[Abstract] [Full Text] [PDF]

Home page
 Alcohol AlcoholHome page
T. Hauge, J. Persson, and K. Sjolund
Neuropeptides in the duodenal mucosa of chronic alcoholic heavy drinkers
Alcohol Alcohol., May 1, 2001; 36(3): 213 - 218.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. Rydning, O. Lyng, S. Aase, and J. E. Gronbech
Substance P may attenuate gastric hyperemia by a mast cell-dependent mechanism in the damaged gastric mucosa
Am J Physiol Gastrointest Liver Physiol, November 1, 1999; 277(5): G1064 - G1073.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
P. Holzer and M. A. Pabst
Visceral Afferent Neurons: Role in Gastric Mucosal Protection
Physiology, October 1, 1999; 14(5): 201 - 206.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online