AJP - Gastrointestinal and Liver Physiology, Vol 270, Issue 3 470-G475, Copyright © 1996 by American Physiological Society
Frequency of gastric pacesetter potential depends on volume and site of distension
H. C. Lin, X. T. Zhao, B. Chung, Y. G. GU and J. D. Elashoff
Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles 90048-1869, USA.
Little is known about the response of the frequency of gastric pacesetter
potential (PP) to luminal distension. When volume distension occurs as a
result of a meal, gastric emptying may play an important role, since the
site of distension shifts as the meal is displaced from the stomach to the
small bowel. In this study, using does equipped with duodenal fistulas and
serosal electrodes on the antrum, we compared the frequency of gastric PP
during the course of gastric emptying while isolating the volume distension
to either the stomach or the small bowel. We found that 1) the frequency of
gastric PP decreased linearly with greater initial meal volume when volume
distension was isolated to either the stomach -P<0.05, analysis of
variance (ANOVA)- or small bowel (P<0.01, ANOVA), and 2) the frequency
of gastric PP decreased linearly with increased volume remaining in the
stomach or increased volume entering the small intestine. We conclude that
the frequency of gastric PP depends on the volume and site of distension.
