AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 270: G1028-G1032, 1996;
0193-1857/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yamaguchi, T.
Right arrow Articles by Ishimura, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamaguchi, T.
Right arrow Articles by Ishimura, Y.

AJP - Gastrointestinal and Liver Physiology, Vol 270, Issue 6 1028-G1032, Copyright © 1996 by American Physiological Society

ARTICLES

Taurocholate induces directional excretion of bilirubin into bile in perfused rat liver

T. Yamaguchi, Y. Wakabayashi, M. Tanaka, T. Sano, H. Ishikawa, H. Nakajima, M. Suematsu and Y. Ishimura
Department of Biochemical Genetics, Tokyo Medical and Dental University, Japan.

The role of taurocholate, one of the major conjugated bile acids present in portal blood, in excretion of bilirubin from liver parenchyma to biliary and vascular compartments was studied in isolated perfused rat liver. Contents of bilirubin and carbon monoxide (CO) in the bile or venous effluents were determined by enzyme-linked immunosorbent microassay with the use of antibilirubin monoclonal antibody 24G7 and myoglobin-assisted spectrophotometry, respectively. In the presence of taurocholate, bilirubin excreted into the biliary compartment constituted greater than 90% of the total bilirubin excreted from the liver (0.26 nmol.min-1.g liver-1), corresponding to 60% of the outflow of CO into the venous effluents. In its absence, however, the total amount of bilirubin excreted into extrahepatic compartments was reduced to 27% of CO flux, and more than 90% of the excreted bilirubin was in the venous effluent. Thus a choleretic bile acid such as taurocholate is necessary for directional transport of bilirubin into bile in the perfused liver preparation.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. Takamiya, M. Murakami, M. Kajimura, N. Goda, N. Makino, Y. Takamiya, T. Yamaguchi, Y. Ishimura, N. Hozumi, and M. Suematsu
Stabilization of mast cells by heme oxygenase-1: an anti-inflammatory role
Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H861 - H870.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
Y. Wakabayashi, R. Takamiya, A. Mizuki, T. Kyokane, N. Goda, T. Yamaguchi, S. Takeoka, E. Tsuchida, M. Suematsu, and Y. Ishimura
Carbon monoxide overproduced by heme oxygenase-1 causes a reduction of vascular resistance in perfused rat liver
Am J Physiol Gastrointest Liver Physiol, November 1, 1999; 277(5): G1088 - G1096.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. Hayashi, R. Takamiya, T. Yamaguchi, K. Matsumoto, S. J. Tojo, T. Tamatani, M. Kitajima, N. Makino, Y. Ishimura, and M. Suematsu
Induction of Heme Oxygenase-1 Suppresses Venular Leukocyte Adhesion Elicited by Oxidative Stress : Role of Bilirubin Generated by the Enzyme
Circ. Res., October 15, 1999; 85(8): 663 - 671.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online