AJP - GI AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 271: G377-G385, 1996;
0193-1857/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Christie, D. M.
Right arrow Articles by Shneider, B. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Christie, D. M.
Right arrow Articles by Shneider, B. L.

AJP - Gastrointestinal and Liver Physiology, Vol 271, Issue 2 377-G385, Copyright © 1996 by American Physiological Society

ARTICLES

Comparative analysis of the ontogeny of a sodium-dependent bile acid transporter in rat kidney and ileum

D. M. Christie, P. A. Dawson, S. Thevananther and B. L. Shneider
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

An apical sodium-dependent bile acid transporter (ASBT) has recently been cloned and characterized in the rat ileum. Northern and Western blotting revealed both the ASBT mRNA and protein in rat kidney. The coding sequence of the kidney transcript was found to be identical to the previously cloned ileal ASBT. Indirect immunofluorescence studies localized the ASBT protein to the apical membrane of the renal proximal convoluted tubule. Kinetic analysis of sodium-dependent taurocholate uptake using membrane vesicles revealed a similar Michaelis-Menten constant value for taurocholate in the kidney and intestine. ASBT protein and function were present in the kidney but not the ileum from 7-day-old rats. On postnatal day 7, there was a sevenfold increase in ASBT steady-state mRNA levels in the kidney relative to the ileum, yet nuclear run-on assays revealed that the nascent transcription rates at this age were virtually the same. This suggests that the difference in the neonatal expression of the ASBT gene in the kidney and ileum may be in part due to differences in mRNA stability.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. Sinha, F. Chen, T. Miloh, R. C. Burns, Z. Yu, and B. L. Shneider
{beta}-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes
Am J Physiol Gastrointest Liver Physiol, November 1, 2008; 295(5): G996 - G1003.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. Trauner and J. L. Boyer
Bile Salt Transporters: Molecular Characterization, Function, and Regulation
Physiol Rev, April 1, 2003; 83(2): 633 - 671.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. M. Nabokina, V. S. Subramanian, and H. M. Said
Comparative analysis of ontogenic changes in renal and intestinal biotin transport in the rat
Am J Physiol Renal Physiol, April 1, 2003; 284(4): F737 - F742.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
G. Gamba
Alternative splicing and diversity of renal transporters
Am J Physiol Renal Physiol, November 1, 2001; 281(5): F781 - F794.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Chen, L. Ma, N. Al-Ansari, and B. Shneider
The Role of AP-1 in the Transcriptional Regulation of the Rat Apical Sodium-dependent Bile Acid Transporter
J. Biol. Chem., October 12, 2001; 276(42): 38703 - 38714.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
S. T. Hwang and S. J. Henning
Ontogenic Regulation of Components of Ileal Bile AcidAbsorption
Experimental Biology and Medicine, July 1, 2001; 226(7): 674 - 680.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. T. Hwang and S. J. Henning
Hormonal regulation of expression of ileal bile acid binding protein in suckling rats
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2000; 278(6): R1555 - R1563.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. Amelsberg, C. Jochims, C. P. Richter, R. Nitsche, and U. R. Folsch
Evidence for an anion exchange mechanism for uptake of conjugated bile acid from the rat jejunum
Am J Physiol Gastrointest Liver Physiol, March 1, 1999; 276(3): G737 - G742.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. A. Weinman, M. W. Carruth, and P. A. Dawson
Bile Acid Uptake via the Human Apical Sodium-Bile Acid Cotransporter Is Electrogenic
J. Biol. Chem., December 25, 1998; 273(52): 34691 - 34695.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. L. Craddock, M. W. Love, R. W. Daniel, L. C. Kirby, H. C. Walters, M. H. Wong, and P. A. Dawson
Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter
Am J Physiol Gastrointest Liver Physiol, January 1, 1998; 274(1): G157 - G169.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. N. Lazaridis, P. Tietz, T. Wu, S. Kip, P. A. Dawson, and N. F. LaRusso
Alternative splicing of the rat sodium/bile acid transporter changes its cellular localization and transport properties
PNAS, September 26, 2000; 97(20): 11092 - 11097.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online