| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Gastrointestinal and Liver Physiology, Vol 271, Issue 3 387-G399, Copyright © 1996 by American Physiological Society
ARTICLES |
J. Malysz, L. Thuneberg, H. B. Mikkelsen and J. D. Huizinga
Intestinal Disease Research Program, McMaster University, Hamilton, Ontario, Canada.
The small intestine of W/Wv mice lacks both the network of interstitial cells of Cajal (ICC), associated with Auerbach's plexus, and pacemaker activity, i.e., it does not generate slow-wave-type action potentials. The W/Wv muscle preparations showed a wide variety of electrical activities, ranging from total quiescence to generation of action potentials at regular or irregular frequency with or without periods of quiescence. The action potentials consisted of a slow component with superimposed spikes, preceded by a slowly developing depolarization and followed by a transient hyperpolarization. The action potentials were completely abolished by L-type Ca2+ channel blockers. W/Wv mice responded to K+ channel blockade (0.5 mM Ba2+ or 10 mM tetraethylammonium chloride) with effects on amplitude, frequency, rate of rise, and duration of the action potentials. In quiescent tissues from W/Wv mice, K+ channel blockade evoked the typical spikelike action potentials. Electron microscopy identified few methylene blue-positive cells in the W/Wv small intestine associated with Auerbach's plexus as individual ICC. Numbers of resident macrophage-like cells (MLC) and fibroblast-like cells (FLC) were significantly changed. Neither FLC nor MLC were part of a network nor did they form specialized junctions with neighboring cells as ICC do. Hence no cell type had replaced ICC at their normal morphological position associated with Auerbach's plexus. ICC were present in W/Wv mice at the deep muscular plexus in normal organization and numbers, indicating that they are not dependent on the Kit protein and do not take part in generation of pacemaker activity.
This article has been cited by other articles:
|
|
 |
|
  S. K. Sarna Are interstitial cells of Cajal plurifunction cells in the gut? Am J Physiol Gastrointest Liver Physiol, February 1, 2008; 294(2): G372 - G390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Forrest, J. D. Huizinga, X.-Y. Wang, L. W. C. Liu, and M. Parsons Increase in stretch-induced rhythmic motor activity in the diabetic rat colon is associated with loss of ICC of the submuscular plexus Am J Physiol Gastrointest Liver Physiol, January 1, 2008; 294(1): G315 - G326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Alberti, H. B. Mikkelsen, X. Y. Wang, M. Diaz, J. O. Larsen, J. D. Huizinga, and M. Jimenez Pacemaker activity and inhibitory neurotransmission in the colon of Ws/Ws mutant rats Am J Physiol Gastrointest Liver Physiol, June 1, 2007; 292(6): G1499 - G1510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. El-Yazbi, W. J. Cho, G. Boddy, R. Schulz, and E. E. Daniel Impact of caveolin-1 knockout on NANC relaxation in circular muscles of the mouse small intestine compared with longitudinal muscles Am J Physiol Gastrointest Liver Physiol, February 1, 2006; 290(2): G394 - G403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-Y. Wang, W. J. E. P. Lammers, P. Bercik, and J. D. Huizinga Lack of pyloric interstitial cells of Cajal explains distinct peristaltic motor patterns in stomach and small intestine Am J Physiol Gastrointest Liver Physiol, September 1, 2005; 289(3): G539 - G549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Remorgida, N. Ragni, S. Ferrero, P. Anserini, P. Torelli, and E. Fulcheri The involvement of the interstitial Cajal cells and the enteric nervous system in bowel endometriosis Hum. Reprod., January 1, 2005; 20(1): 264 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. Daniel, G. Boddy, A. Bong, and W. Cho A new model of pacing in the mouse intestine Am J Physiol Gastrointest Liver Physiol, February 1, 2004; 286(2): G253 - G262. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Chi and T. L. Powley c-Kit mutant mouse behavioral phenotype: altered meal patterns and CCK sensitivity but normal daily food intake and body weight Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R1170 - R1183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-Y. Wang, S. M. Ward, W. T. Gerthoffer, and K. M. Sanders PKC-{epsilon} translocation in enteric neurons and interstitial cells of Cajal in response to muscarinic stimulation Am J Physiol Gastrointest Liver Physiol, August 8, 2003; 285(3): G593 - G601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rich, S. M. Miller, S. J. Gibbons, J. Malysz, J. H. Szurszewski, and G. Farrugia Local presentation of Steel factor increases expression of c-kit immunoreactive interstitial cells of Cajal in culture Am J Physiol Gastrointest Liver Physiol, February 1, 2003; 284(2): G313 - G320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I Takayama, Y Daigo, S M Ward, K M Sanders, R L Walker, B Horowitz, T Yamanaka, and M A Fujino Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/WV mouse jejunum Gut, June 1, 2002; 50(6): 790 - 796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Huizinga Physiology and Pathophysiology of the Interstitial Cell of Cajal: From Bench to Bedside: II. Gastric motility: lessons from mutant mice on slow waves and innervation Am J Physiol Gastrointest Liver Physiol, November 1, 2001; 281(5): G1129 - G1134. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Fujita, T. Takeuchi, N. Saitoh, J. Hanai, and F. Hata Expression of Ca2+-activated K+ channels, SK3, in the interstitial cells of Cajal in the gastrointestinal tract Am J Physiol Cell Physiol, November 1, 2001; 281(5): C1727 - C1733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Malysz, G. Donnelly, and J. D. Huizinga Regulation of slow wave frequency by IP3-sensitive calcium release in the murine small intestine Am J Physiol Gastrointest Liver Physiol, March 1, 2001; 280(3): G439 - G448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Donnelly, T. D. Jackson, K. Ambrous, J. Ye, A. Safdar, L. Farraway, and J. D. Huizinga The myogenic component in distention-induced peristalsis in the guinea pig small intestine Am J Physiol Gastrointest Liver Physiol, March 1, 2001; 280(3): G491 - G500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. F. Lee, L. Thuneberg, I. Berezin, and J. D. Huizinga Generation of slow waves in membrane potential is an intrinsic property of interstitial cells of Cajal Am J Physiol Gastrointest Liver Physiol, August 1, 1999; 277(2): G409 - G423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Radojevic, D. M. McKay, M. Merger, B. A. Vallance, S. M. Collins, and K. Croitoru Characterization of enteric functional changes evoked by in vivo anti-CD3 T cell activation Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1999; 276(3): R715 - R723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Hagger, S. Gharaie, C. Finlayson, and D. Kumar Regional and transmural density of interstitial cells of Cajal in human colon and rectum Am J Physiol Gastrointest Liver Physiol, December 1, 1998; 275(6): G1309 - G1316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. Daniel, Y.-F. Wang, and F. S. Cayabyab Role of gap junctions in structural arrangements of interstitial cells of Cajal and canine ileal smooth muscle Am J Physiol Gastrointest Liver Physiol, June 1, 1998; 274(6): G1125 - G1141. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
