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Am J Physiol Gastrointest Liver Physiol 271: G555-G560, 1996;
0193-1857/96 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 271, Issue 4 555-G560, Copyright © 1996 by American Physiological Society

ARTICLES

A low-protein diet ameliorates disrupted diurnal locomotor activity in rats after portacaval anastomosis

P. E. Steindl, D. L. Coy, B. Finn, P. C. Zee and A. T. Blei
Department of Medicine, Lakeside Veterans Affairs Medical Center, Chicago, Illinois, USA.

In previous studies we noted a disruption of the circadian locomotor activity rhythm in rats after portacaval anastomosis (PCA). To examine whether this abnormality is related to factors that aggravate hepatic encephalopathy in humans, we studied the effect of dietary formulation and protein content on body weight, locomotor activity, and entrainment to the light-dark cycle in rats after PCA or sham operation. Postoperative weight loss was prevented by pair-feeding with a purified liquid diet. However, the behavioral abnormalities persisted in PCA rats fed a high-protein diet, with a reduction in total activity and entrainment to the light-dark cycle. These were ameliorated by a low dietary protein content. Since this treatment reduces the load of gut-derived nitrogenous substances that might alter brain metabolism, our data strengthen the hypothesis that the abnormal circadian activity patterns in PCA rats may be part of the spectrum of hepatic encephalopathy.


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J. Cordoba, J. Dupuis, J. Gottstein, and A. T. Blei
Stenosis of a portacaval anastomosis affects circadian locomotor activity in the rat: a multivariable analysis
Am J Physiol Gastrointest Liver Physiol, December 1, 1997; 273(6): G1218 - G1225.
[Abstract] [Full Text] [PDF]


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