| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Gastrointestinal and Liver Physiology, Vol 271, Issue 5 849-G857, Copyright © 1996 by American Physiological Society
ARTICLES |
M. Kadowaki, P. R. Wade and M. D. Gershon
Department of Anatomy and Cell Biology, College of Physicians and Surgeons, Columbia University, New York 10032, USA.
The roles of 5-hydroxytryptamine3 (5-HT3), 5-HT4, and nicotinic receptors in the peristaltic reflex were investigated in isolated segments of guinea pig distal colon. The reflex assessed by measuring the propulsion of solid pellets, was affected neither by 5-HT3-selective antagonists (ondansetron granisetron) nor by 5-HT4-selective antagonists (SDZ-205-557, GR-113808A, SB-204070) applied individually (1.0 microM); nevertheless, the reflex was inhibited by combining these antagonists or by applying a 5-HT3/5-HT4 dual antagonist (FK-1052). Hexamethonium abolished the peristaltic reflex at 100 microM, but not at 10-32 microM. In contrast, the peristaltic reflex was inhibited when hexamethonium (32 microM was combined with either a 5-HT3- or 5-HT4-selective antagonist (1.0 microM). These observations suggest that 5-HT3, 5-HT4, and nicotinic receptors participate in the initiation and/or propagation of the peristaltic reflex. The data are consistent with the idea that these receptors are arranged in parallel in the neural pathways that mediate the peristaltic reflex in the distal colon.
This article has been cited by other articles:
|
|
 |
|
  R. M. Gwynne and J. C. Bornstein Local inhibitory reflexes excited by mucosal application of nutrient amino acids in guinea pig jejunum Am J Physiol Gastrointest Liver Physiol, June 1, 2007; 292(6): G1660 - G1670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Sarna Enteric descending and afferent neural signaling stimulated by giant migrating contractions: essential contributing factors to visceral pain Am J Physiol Gastrointest Liver Physiol, February 1, 2007; 292(2): G572 - G581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Lomax, J. R. O'Hara, N. P. Hyland, G. M. Mawe, and K. A. Sharkey Persistent alterations to enteric neural signaling in the guinea pig colon following the resolution of colitis Am J Physiol Gastrointest Liver Physiol, February 1, 2007; 292(2): G482 - G491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, V. Martinez, H. Kimura, and Y. Tache 5-Hydroxytryptophan activates colonic myenteric neurons and propulsive motor function through 5-HT4 receptors in conscious mice Am J Physiol Gastrointest Liver Physiol, January 1, 2007; 292(1): G419 - G428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. C. Lin, C. Neevel, and J. H. Chen Slowing intestinal transit by PYY depends on serotonergic and opioid pathways Am J Physiol Gastrointest Liver Physiol, April 1, 2004; 286(4): G558 - G563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Linden, J.-X. Chen, M. D. Gershon, K. A. Sharkey, and G. M. Mawe Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis Am J Physiol Gastrointest Liver Physiol, June 9, 2003; 285(1): G207 - G216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-T. Liu, S. Rayport, Y. Jiang, D. L. Murphy, and M. D. Gershon Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter Am J Physiol Gastrointest Liver Physiol, December 1, 2002; 283(6): G1398 - G1411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Li, C. P. Johnson, M. B. Adams, and S. K. Sarna Cholinergic and nitrergic regulation of in vivo giant migrating contractions in rat colon Am J Physiol Gastrointest Liver Physiol, September 1, 2002; 283(3): G544 - G552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A E Bharucha, M Camilleri, S Haydock, I Ferber, D Burton, S Cooper, D Tompson, K Fitzpatrick, R Higgins, and A R Zinsmeister Effects of a serotonin 5-HT4 receptor antagonist SB-207266 on gastrointestinal motor and sensory function in humans Gut, November 1, 2000; 47(5): 667 - 674. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Pan and M. D. Gershon Activation of Intrinsic Afferent Pathways in Submucosal Ganglia of the Guinea Pig Small Intestine J. Neurosci., May 1, 2000; 20(9): 3295 - 3309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-t. Liu, S. Seino, and A. L. Kirchgessner Identification and Characterization of Glucoresponsive Neurons in the Enteric Nervous System J. Neurosci., December 1, 1999; 19(23): 10305 - 10317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zhai, M. D. Gershon, J. H. Walsh, H. C. Wong, and A. L. Kirchgessner Inward Currents in Neurons from Newborn Guinea Pig Intestine: Mediation by 5-Hydroxytryptamine Type 3 Receptors J. Pharmacol. Exp. Ther., October 1, 1999; 291(1): 374 - 382. [Abstract] [Full Text]
|
|
|
|
|
|
A. L. Obaid, T. Koyano, J. Lindstrom, T. Sakai, and B. M. Salzberg Spatiotemporal Patterns of Activity in an Intact Mammalian Network with Single-Cell Resolution: Optical Studies of Nicotinic Activity in an Enteric Plexus J. Neurosci., April 15, 1999; 19(8): 3073 - 3093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. -G. Jin, A. E. Foxx-Orenstein, and J. R. Grider Propulsion in Guinea Pig Colon Induced by 5-Hydroxytryptamine (HT) via 5-HT4 and 5-HT3 Receptors J. Pharmacol. Exp. Ther., January 1, 1999; 288(1): 93 - 97. [Abstract] [Full Text]
|
|
|
|
|
|
E. Fiorica-Howells, R. Hen, J. Gingrich, Z. Li, and M. D. Gershon 5-HT2A receptors: location and functional analysis in intestines of wild-type and 5-HT2A knockout mice Am J Physiol Gastrointest Liver Physiol, May 1, 2002; 282(5): G877 - G893. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
