AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 271: G969-G979, 1996;
0193-1857/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hammond, K. A.
Right arrow Articles by Diamond, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hammond, K. A.
Right arrow Articles by Diamond, J.

AJP - Gastrointestinal and Liver Physiology, Vol 271, Issue 6 969-G979, Copyright © 1996 by American Physiological Society

ARTICLES

Simultaneous manipulation of intestinal capacities and nutrient loads in mice

K. A. Hammond, M. Lam, K. C. Lloyd and J. Diamond
Department of Physiology, School of Medicine, University of California, Los Angeles 90095-1751, USA.

To study the relationship between capacity and load in the small intestine, we simultaneously varied dietary nutrient load and intestinal capacity in mice. Intestinal transection alone caused an increase in intestinal mass, because of increased serosal mass. Because virgin mouse intestine possesses 180% reserve uptake capacity before resection and the intestine regenerates after resection, resection of up to 50% had no effect on food intake, digestive efficiency, intestinal brush-border glucose uptake rate, or mass of all organs measured except the cecum. Regeneration of intestinal mass and glucose uptake capacity was quantitatively complete, because intestinal mass 10 wk after resection was similar to that in unresected mice. Resected intestinal mass in lactating mice was four times larger than that immediately after resection in virgin mice. Cecal mass increased in 50%-resected lactating mice with high food intakes, suggesting nutrient spillage into the distal gut as a signal for regeneration. Mice failed to survive 70% resection of the intestine, possibly because intestinal reserve uptake capacity was exhausted immediately after surgery, making regeneration impossible.


This article has been cited by other articles:


Home page
 J. Exp. Biol.Home page
D. M. Kristan
Effects of intestinal nematodes during lactation: consequences for host morphology, physiology and offspring mass
J. Exp. Biol., December 15, 2002; 205(24): 3955 - 3965.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. W. Musch, C. Bookstein, F. Rocha, A. Lucioni, H. Ren, J. Daniel, Y. Xie, R. L. McSwine, M. C. Rao, J. Alverdy, et al.
Region-specific adaptation of apical Na/H exchangers after extensive proximal small bowel resection
Am J Physiol Gastrointest Liver Physiol, October 1, 2002; 283(4): G975 - G985.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. M. Secor, E. E. Whang, J. S. Lane, S. W. Ashley, and J. Diamond
Luminal and systemic signals trigger intestinal adaptation in the juvenile python
Am J Physiol Gastrointest Liver Physiol, December 1, 2000; 279(6): G1177 - G1187.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. P. O'Connor, M. M. Lam, and J. Diamond
Magnitude of functional adaptation after intestinal resection
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1999; 276(5): R1265 - R1275.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online