AJP - Gastrointestinal and Liver Physiology, Vol 272, Issue 1 147-G153, Copyright © 1997 by American Physiological Society

ARTICLES

Local regulation of ileal tone in healthy humans

B. Coffin, M. Lemann, B. Flourie, P. Jouet, J. C. Rambaud and R. Jian
Unite de Recherche sur les Fonctions Intestinales, le Metabolisme et la Nutrition, Institut National de la Sante et de la Recherche Medicale U 290, Hopital Saint-Lazare, Paris, France.

We previously showed that a meal induced, in the human terminal ileum, a delayed tonic relaxation, which could be related to the ileal delivery of meal residues and/or endogenous secretions released by a meal. In this study, we assessed the effects of some components of the ileal contents on its motor activity. In six healthy subjects, we studied ileal tonic and phasic motility in response to the infusion into the terminal ileum of different isotonic solutions: saline, glycochenodeoxycholic acid (GDCA), triglycerides, and short-chain fatty acids (SCFA). Tonic activity was not modified by saline, whereas it was significantly decreased by GDCA and triglycerides (maximal increase in intrabag volume 139 +/- 7% and 152 +/- 16%, respectively, P < 0.01), and significantly increased by SCFA (maximal decrease in intrabag volume 72 +/- 4%, P < 0.01). No significant change of phasic activity was evidenced with either solution. We conclude that 1) bile acids and triglycerides not absorbed in the more proximal gut could be involved in the ileal relaxation occurring after eating and 2) local stimulation of chemoreceptors is of importance in the regulation of ileal motility.

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