AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 272: G23-G30, 1997;
0193-1857/97 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yamanaka, K.
Right arrow Articles by Steer, M. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamanaka, K.
Right arrow Articles by Steer, M. L.

AJP - Gastrointestinal and Liver Physiology, Vol 272, Issue 1 23-G30, Copyright © 1997 by American Physiological Society

ARTICLES

Protective effects of prostaglandin E1 on acute lung injury of caerulein-induced acute pancreatitis in rats

K. Yamanaka, A. K. Saluja, G. E. Brown, Y. Yamaguchi, B. Hofbauer and M. L. Steer
Department of Surgery, Beth Israel Hospital, Boston, Massachusetts, USA.

Infusion of a supramaximally stimulating dose of the pancreatic secretagogue caerulein (10 micrograms.kg-1.h-1) for 4 h induces interstitial edematous acute pancreatitis in rats. This model of acute pancreatitis is associated with evidence of acute lung injury, including sequestered neutrophils within the pulmonary microvasculature, increased microvascular permeability, and interstitial pulmonary edema. Infusion of prostaglandin E1 (PGE1; 50 ng.kg-1.min-1) along with caerulein does not alter the severity of secretagogue-induced pancreatitis, but it does reduce the severity of pancreatitis-associated acute lung injury. The rise in lung weight, lung water content, and pulmonary microvascular permeability and the sequestration of neutrophils within the pulmonary microvasculature that accompany secretagogue-induced pancreatitis are all reduced by infusion of PGE1. Infusion of PGE1 does not interfere with polymorphonuclear neutrophil sequestration in the pancreas or reduce the enhanced expression of CD11b/c receptors on circulating neutrophils. Our observations indicate that PGE1 reduces the severity of pancreatitis-associated acute lung injury by preventing neutrophil sequestration within the lung. We speculate that PGE1 interferes with neutrophil sequestration by dilating pulmonary vasculature, increasing pulmonary flow rate, and reducing neutrophil-endothelial cell interaction and attachment.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Severgnini, S. Takahashi, L. M. Rozo, R. J. Homer, C. Kuhn, J. W. Jhung, G. Perides, M. Steer, P. M. Hassoun, B. L. Fanburg, et al.
Activation of the STAT pathway in acute lung injury
Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1282 - L1292.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. L. Frossard, A. K. Saluja, N. Mach, H. S. Lee, L. Bhagat, A. Hadenque, L. Rubbia-Brandt, G. Dranoff, and M. L. Steer
In vivo evidence for the role of GM-CSF as a mediator in acute pancreatitis-associated lung injury
Am J Physiol Lung Cell Mol Physiol, September 1, 2002; 283(3): L541 - L548.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
G Eibl, H G Hotz, J Faulhaber, M Kirchengast, H J Buhr, and T. Foitzik
Effect of endothelin and endothelin receptor blockade on capillary permeability in experimental pancreatitis
Gut, March 1, 2000; 46(3): 390 - 394.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online