AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 272: G224-G232, 1997;
0193-1857/97 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mochiki, E.
Right arrow Articles by Itoh, Z.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mochiki, E.
Right arrow Articles by Itoh, Z.

AJP - Gastrointestinal and Liver Physiology, Vol 272, Issue 2 224-G232, Copyright © 1997 by American Physiological Society

ARTICLES

Motilin is a biosignal controlling cyclic release of pancreatic polypeptide via the vagus in fasted dogs

E. Mochiki, A. Inui, M. Satoh, A. Mizumoto and Z. Itoh
Gastrointestinal Research Laboratories, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.

The mechanism of associated fluctuations in plasma motilin and pancreatic polypeptide (PP) concentrations was studied in fasted conscious dogs while gastric motility was monitored. Plasma motilin and PP concentrations were measured by radioimmunoassay. In intact normal dogs, exogenous motilin (0.03-0.3 g/kg) stimulated dose-related release of PP, but PP did not stimulate motilin release. Motilin-induced PP release was completely inhibited by pretreatment with cholinergic blockers and a 5-hydroxytryptamine3 (5-HT3) receptor antagonist, and by vagotomy. The cyclic release of PP was abolished after vagotomy and duodenectomy. However, PP release stimulated by exogenous motilin was apparent after duodenectomy but not after vagotomy. In conclusion, motilin appears to stimulate PP release via vagal, cholinergic muscarinic pathways involving 5-HT3 receptors and to act as a biosignal controlling PP release by mediating the interdigestive periodic changes in the duodenum to the center of the autonomic nervous system. This represents a new role for motilin.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
S. Stanley, K. Wynne, B. McGowan, and S. Bloom
Hormonal Regulation of Food Intake
Physiol Rev, October 1, 2005; 85(4): 1131 - 1158.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
K. Wynne, S. Stanley, B. McGowan, and S. Bloom
Appetite control
J. Endocrinol., February 1, 2005; 184(2): 291 - 318.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
N. Ueno, A. Inui, A. Asakawa, F. Takao, A. Ichibangase, Y. Komatsu, and M. Kasuga
Erythromycin Administration Before Sleep is Effective in Decreasing Fasting Hyperglycemia in Type 2 Diabetic Patients
Diabetes Care, March 1, 2001; 24(3): 607 - 607.
[Full Text]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
H. Suzuki, E. Mochiki, N. Haga, M. Satoh, A. Mizumoto, and Z. Itoh
Motilin controls cyclic release of insulin through vagal cholinergic muscarinic pathways in fasted dogs
Am J Physiol Gastrointest Liver Physiol, January 1, 1998; 274(1): G87 - G95.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online