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Am J Physiol Gastrointest Liver Physiol 272: G1550-G1559, 1997;
0193-1857/97 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 272, Issue 6 1550-G1559, Copyright © 1997 by American Physiological Society

ARTICLES

Effects of telenzepine and L-364,718 on canine pancreatic secretion before and after vagotomy

E. Niebergall-Roth, S. Teyssen, D. Wetzel, M. Hartel, C. Beglinger, R. L. Riepl and M. V. Singer
Department of Medicine IV (Gastroenterology), University Hospital of Heidelberg at Mannheim, Germany.

In six conscious dogs we compared the action of the M1-receptor antagonist telenzepine (20.25-81.0 nmol.kg-1.h-1), the cholecystokinin (CCK) antagonist L-364,718 (0.025-0.1 mg.kg-1.h-1), and combinations of both on the pancreatic secretory response to intraduodenal tryptophan, given against a secretin background before and after truncal vagotomy. Before vagotomy, the higher doses of telenzepine and of L-364,718 significantly (P < 0.05) decreased the protein response to tryptophan by up to 97%. After vagotomy, all doses of L-364,718 abolished the protein response, whereas telenzepine had no further effect. Before and after vagotomy, all combinations abolished the protein response. The plasma CCK-like immunoreactivity basally, during secretin, and in response to tryptophan was not altered by vagotomy, telenzepine, and/or L-364,718. These findings indicate that in dogs 1) potentiation exists between M1 receptors and CCK for stimulation of the pancreatic enzyme response to intraduodenal tryptophan, 2) the cholinergic fibers of the enteropancreatic reflex activated by tryptophan run within the vagus nerves and end at least in part on M1 receptors, 3) CCK acts in part independently of the vagal nerves, and 4) the CCK release by intestinal tryptophan is not influenced by vagotomy, telenzepine, and/or L-364,718.


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E. Niebergall-Roth, S. Teyssen, and M. V. Singer
Effects of M1 and CCK antagonists on latency of pancreatic amylase response to intestinal stimulants
Am J Physiol Gastrointest Liver Physiol, August 1, 2000; 279(2): G411 - G416.
[Abstract] [Full Text] [PDF]


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