AJP - GI Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 273: G93-G105, 1997;
0193-1857/97 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by London, R. M.
Right arrow Articles by Forte, L. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by London, R. M.
Right arrow Articles by Forte, L. R.

AJP - Gastrointestinal and Liver Physiology, Vol 273, Issue 1 93-105, Copyright © 1997 by American Physiological Society

ARTICLES

Signal transduction pathways via guanylin and uroguanylin in stomach and intestine

R. M. London, W. J. Krause, X. Fan, S. L. Eber and L. R. Forte
Truman Veterans Affairs Medical Center, Columbia, Missouri 65212, USA.

Guanylin and uroguanylin are peptides that activate receptor guanylate cyclases (GCs) and elicit increased intestinal secretion. Bacteria that cause traveler's diarrhea produce heat-stable toxins (STs) that mimic this action. Investigation of the distribution and identity of receptor GCs in the gastrointestinal tract of rats revealed that receptors were localized to epithelial cells in stomach and intestine. Clusters of cells in gastric mucosa and enterocytes lining the intestine exhibited specific binding of 125I-labeled ST. Ligated loops of stomach and intestine treated with intraluminal ST had significant increases in guanosine 3',5'-cyclic monophosphate (cGMP), with duodenum exhibiting the greatest response. Expression of guanylate cyclase C (GCC) mRNA and a truncated, GCC-like mRNA was found in both stomach and intestine. Both mRNAs were isolated as cDNAs encoding the GC catalytic domain. The 0.9-kilobase (kb) cDNA is 99.8% identical to GCC, whereas the truncated, 0.75-kb GCC-like cDNA has a 159-nucleotide deletion and is 96.6% identical to GCC at the protein level. Uroguanylin and guanylin mRNAs were detected in stomach and intestine. Uroguanylin mRNA was most abundant in small intestine, whereas guanylin mRNA was highest in large intestine. Thus the stomach and intestine are targets for regulation of transport by guanylin and uroguanylin via cGMP.


This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
M. Jaleel, R. M. London, S. L. Eber, L. R. Forte, and S. S. Visweswariah
Expression of the Receptor Guanylyl Cyclase C and Its Ligands in Reproductive Tissues of the Rat: A Potential Role for a Novel Signaling Pathway in the Epididymis
Biol Reprod, December 1, 2002; 67(6): 1975 - 1980.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
L. Cui, R. K. Blanchard, L. M. Coy, and R. J. Cousins
Prouroguanylin Overproduction and Localization in the Intestine of Zinc-Deficient Rats
J. Nutr., November 1, 2000; 130(11): 2726 - 2732.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Shailubhai, H. H. Yu, K. Karunanandaa, J. Y. Wang, S. L. Eber, Y. Wang, N. S. Joo, H. D. Kim, B. W. Miedema, S. Z. Abbas, et al.
Uroguanylin Treatment Suppresses Polyp Formation in the ApcMin/+ Mouse and Induces Apoptosis in Human Colon Adenocarcinoma Cells via Cyclic GMP
Cancer Res., September 1, 2000; 60(18): 5151 - 5157.
[Abstract] [Full Text]

Home page
 Pharmacol. Rev.Home page
K. A. Lucas, G. M. Pitari, S. Kazerounian, I. Ruiz-Stewart, J. Park, S. Schulz, K. P. Chepenik, and S. A. Waldman
Guanylyl Cyclases and Signaling by Cyclic GMP
Pharmacol. Rev., September 1, 2000; 52(3): 375 - 414.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. D'Este, H. Kulaksiz, U. Rausch, R. Vaccaro, T. Wenger, Y. Tokunaga, T. G. Renda, and Y. Cetin
Expression of guanylin in "pars tuberalis-specific cells" and gonadotrophs of rat adenohypophysis
PNAS, February 1, 2000; 97(3): 1131 - 1136.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. R. Forte, R. M. London, R. H. Freeman, and W. J. Krause
Guanylin peptides: renal actions mediated by cyclic GMP
Am J Physiol Renal Physiol, February 1, 2000; 278(2): F180 - F191.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
T. Kita, K. Kitamura, J. Sakata, and T. Eto
Marked increase of guanylin secretion in response to salt loading in the rat small intestine
Am J Physiol Gastrointest Liver Physiol, November 1, 1999; 277(5): G960 - G966.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. M. London, S. L. Eber, S. S. Visweswariah, W. J. Krause, and L. R. Forte
Structure and activity of OK-GC: a kidney receptor guanylate cyclase activated by guanylin peptides
Am J Physiol Renal Physiol, June 1, 1999; 276(6): F882 - F891.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
X. Fan, F. K. Hamra, R. M. London, S. L. Eber, W. J. Krause, R. H. Freeman, C. E. Smith, M. G. Currie, and L. R. Forte
Structure and activity of uroguanylin and guanylin from the intestine and urine of rats
Am J Physiol Endocrinol Metab, November 1, 1997; 273(5): E957 - E964.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online