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AJP - Gastrointestinal and Liver Physiology, Vol 273, Issue 2 559-G563, Copyright © 1997 by American Physiological Society
ARTICLES |
W. T. Chance, T. Foley-Nelson, I. Thomas and A. Balasubramaniam
Medical Research Service, Department of Veterans Affairs, Cincinnati, Ohio, USA.
Maintaining rats on total parenteral nutrition (TPN) for 6 days significantly reduced mass (-34%), protein (-32%), and DNA (-35%) in small intestine and colon (29-37% decrease). Coinfusion of glucagon-like peptide-2 (GLP-2) normalized each of these variables in duodenum, jejunum, and ileum, but not in colon. Histological analysis of tissue revealed normal mucosa thickness and villus height in small intestine of GLP-2-treated rats, whereas nontreated rats maintained on TPN exhibited villus shortening (-30%) and thinning (-23%) of mucosa. These results suggest that hormonal alterations may be more important than an absence of luminal nutrition in TPN-associated mucosal changes. Additionally, GLP-2 normalization of gut mucosa permits accurate assessment of the influence of reversal of hypoplasia on gut barrier function.
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