| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Gastrointestinal and Liver Physiology, Vol 273, Issue 3 586-G601, Copyright © 1997 by American Physiological Society
ARTICLES |
E. F. Grady, S. K. Bohm and N. W. Bunnett
Department of Surgery, University of California, San Francisco 94143-0660, USA.
Cellular responses to agonists of G protein-coupled receptors are rapidly attenuated. Mechanisms of signal attenuation include ligand removal from the extracellular fluid and receptor desensitization, endocytosis, and downregulation. Cell surface peptidases degrade neuropeptides in the extracellular fluid and thereby terminate their biological actions. G protein receptor kinases and second messenger kinases phosphorylate receptors, permit interaction with arrestins, and thus uncouple receptors from G proteins to mediate desensitization. Agonist-induced receptor endocytosis contributes to desensitization by depleting the cell surface of high-affinity receptors, while recycling of internalized receptors mediates resensitization of cellular responses. Receptor downregulation is a form of desensitization that occurs during continuous, long-term exposure of cells to receptor agonists. Downregulation is characterized by the depletion of the cellular receptor content due to alterations in the rate of receptor degradation and synthesis. These regulatory mechanisms are important, for they govern the ability of cells to respond to agonists.
This article has been cited by other articles:
|
|
 |
|
  R. D. Reidelberger, A. C. Haver, P. K. Chelikani, and J. L. Buescher Effects of different intermittent peptide YY (3-36) dosing strategies on food intake, body weight, and adiposity in diet-induced obese rats Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R449 - R458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. Chelikani, A. C. Haver, and R. D. Reidelberger Effects of intermittent intraperitoneal infusion of salmon calcitonin on food intake and adiposity in obese rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R1798 - R1808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. Chelikani, A. C. Haver, and R. D. Reidelberger Intermittent intraperitoneal infusion of peptide YY(3-36) reduces daily food intake and adiposity in obese rats Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R39 - R46. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Huang, S. Mahavadi, W. Sriwai, J. R. Grider, and K. S. Murthy Cross-regulation of VPAC2 receptor desensitization by M3 receptors via PKC-mediated phosphorylation of RKIP and inhibition of GRK2 Am J Physiol Gastrointest Liver Physiol, March 1, 2007; 292(3): G867 - G874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. Chelikani, A. C. Haver, J. R. Reeve Jr., D. A. Keire, and R. D. Reidelberger Daily, intermittent intravenous infusion of peptide YY(3-36) reduces daily food intake and adiposity in rats Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2006; 290(2): R298 - R305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. W. Tawfeek and A. B. Abou-Samra Important role for the V-type H+-ATPase and the Golgi apparatus in the recycling of PTH/PTHrP receptor Am J Physiol Endocrinol Metab, May 1, 2004; 286(5): E704 - E710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Li, J. F. Wen, J. Y. Jin, H. Jin, H. S. Ann, S. Z. Kim, S. H. Kim, H. S. Lee, and K. W. Cho Histamine inhibits atrial myocytic ANP release via H2 receptor-cAMP-protein kinase signaling Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R380 - R393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Blaukat, P. Micke, I. Kalatskaya, A. Faussner, and W. Muller-Esterl Regulation of Cardiovascular Signaling by Kinins and Products of Similar Converting Enzyme Systems: Downregulation of bradykinin B2 receptor in human fibroblasts during prolonged agonist exposure Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H1909 - H1916. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Jaye, H. A. Edens, L. Mazzucchelli, and C. A. Parkos Novel G Protein-Coupled Responses in Leukocytes Elicited by a Chemotactic Bacteriophage Displaying a Cell Type-Selective Binding Peptide J. Immunol., June 15, 2001; 166(12): 7250 - 7259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. V. Sitaraman, M. Si-Tahar, D. Merlin, G. R. Strohmeier, and J. L. Madara Polarity of A2b adenosine receptor expression determines characteristics of receptor desensitization Am J Physiol Cell Physiol, June 1, 2000; 278(6): C1230 - C1236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Kroog, X. Jian, L. Chen, J. K. Northup, and J. F. Battey Phosphorylation Uncouples the Gastrin-releasing Peptide Receptor from Gq J. Biol. Chem., December 17, 1999; 274(51): 36700 - 36706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Duan, C. M. Anderson, B. A. Stein, and R. A. Swanson Glutamate Induces Rapid Upregulation of Astrocyte Glutamate Transport and Cell-Surface Expression of GLAST J. Neurosci., December 1, 1999; 19(23): 10193 - 10200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ishibashi, A. Dinudom, K. F. Harvey, S. Kumar, J. A. Young, and D. I. Cook Na+-H+ exchange in salivary secretory cells is controlled by an intracellular Na+ receptor PNAS, August 17, 1999; 96(17): 9949 - 9953. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E P Bouras, M Camilleri, D D Burton, and S McKinzie Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans Gut, May 1, 1999; 44(5): 682 - 686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. V. Lissin, R. C. Carroll, R. A. Nicoll, R. C. Malenka, and M. v. Zastrow Rapid, Activation-Induced Redistribution of Ionotropic Glutamate Receptors in Cultured Hippocampal Neurons J. Neurosci., February 15, 1999; 19(4): 1263 - 1272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gama and G. E. Breitwieser A Carboxyl-terminal Domain Controls the Cooperativity for Extracellular Ca2+ Activation of the Human Calcium Sensing Receptor. A STUDY WITH RECEPTOR-GREEN FLUORESCENT PROTEIN FUSIONS J. Biol. Chem., November 6, 1998; 273(45): 29712 - 29718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Feng, J. Zhang, L. S. Barak, T. Meyer, M. G. Caron, and Y. A. Hannun Visualization of Dynamic Trafficking of a Protein Kinase C beta II/Green Fluorescent Protein Conjugate Reveals Differences in G Protein-coupled Receptor Activation and Desensitization J. Biol. Chem., April 24, 1998; 273(17): 10755 - 10762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ichikawa Activity patterns of neurosecretory cells releasing pheromonotropic neuropeptides in the moth Bombyx mori PNAS, March 31, 1998; 95(7): 4055 - 4060. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
