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Am J Physiol Gastrointest Liver Physiol 273: G763-G768, 1997;
0193-1857/97 $5.00
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Vol. 273, Issue 4, G763-G768, October 1997

THEME
I. Neutrophil adhesive interactions with intestinal epithelium*

Charles A. Parkos

Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322

In many inflammatory conditions of the gastrointestinal tract, disease activity and patient symptoms correlate with the histological finding of neutrophil (PMN) migration across the epithelium. PMN interactions with intestinal epithelium can influence epithelial functions ranging from barrier maintenance to electrolyte secretion. Additionally, PMN recruitment to the epithelium can be modulated by epithelial interactions with luminal enteric pathogens. Adhesive interactions between PMN and intestinal epithelial cells have been shown to be distinct from interactions of PMN with endothelia. In particular, PMN transepithelial migration is modulated by a distinct array of cytokines including interferon-gamma and interleukin-4 and requires the PMN beta 2-integrin CD11b/CD18 but is independent of CD11a/CD18, selectins, and intercellular adhesion molecule 1. Additionally, an integral membrane protein termed CD47 has recently been shown to play an important role in PMN transepithelial migration at point(s) subsequent to initial adhesive interactions. This article provides a brief overview of PMN interactions with epithelia and their functional consequences in relation to inflammatory disease.

interferon-gamma ; CD47; CD11b/CD18; selectins; inflammation; intercellular adhesion molecule 1; transepithelial migration

* First in a series of invited articles on Cell Adhesion and Migration.




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