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e
meryüz1,
en2,kun2,Departments of 1 Gastroenterology and 2 Physiology, School of Medicine, Marmara University, Haydarpasa 81326, Istanbul, Turkey; and 3 Fundacion Jimenez Diaz, Departamento de Metabolismo Nutricion y Hormonas, 28040 Madrid, Spain
Exogenous administration of
glucagon-like peptide-1-(7
36) amide (GLP-1), an insulinotropic
hormone, inhibits gastric emptying and acid secretion in humans. The
role of GLP-1 as a regulator of gastric function is elusive. In gastric
fistula rats, vagal afferent denervation and peripheral administration
of the GLP-1 receptor antagonist exendin(939) amide enhanced
emptying of a glucose meal, whereas intracerebroventricular exendin was
ineffective. The rate of saline emptying was attenuated by peripheral
as well as by central administration of GLP-1, and pretreatment with
exendin by the respective routes reversed the inhibition by GLP-1.
Vagal afferent denervation abolished the central and peripheral action of GLP-1 on gastric emptying. Neither peripheral cholinergic nor adrenergic blockade altered the delay of methyl cellulose meal emptying
by intracisternal GLP-1 injection. Acid secretion in conscious
pylorus-ligated rats was inhibited by intracisternal GLP-1
administration, whereas systemic GLP-1 was ineffective. These results
support the notion that GLP-1 receptors participate in the central and
peripheral regulation of gastric function. Furthermore, vagal afferent
nerves mediate the inhibitory action of GLP-1 on gastric motor
function. GLP-1 may be a candidate brain-gut peptide that acts as a
physiological modulator of gastric function.
acid secretion; glucose; feeding behavior; exendin
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