| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1-Acid glycoprotein reduces local and
remote injuries after intestinal ischemia in the rat
Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115
The aim of this study was to look at the role
of 
1-acid glycoprotein as a natural anti-inflammatory
agent with particular respect to its antineutrophil and anticomplement
activity. A recombinantly engineered form of sialyl Lewisx
(sLex)-bearing 1-acid glycoprotein (sAGP)
was administered intravenously to pentobarbital-anesthetized rats after
50 min of intestinal ischemia just before 4 h of reperfusion. A
non-sLex-bearing form of AGP (nsAGP) was used as control.
sAGP-treated animals had a 62% reduction (P < 0.05) in
remote lung injury, assessed by 125I-albumin permeability,
compared with those treated with nsAGP (permeability index of
3.61 ± 0.15 × 10
3 and
5.18 ± 0.67 × 103, respectively). There was a
reduction in pulmonary myeloperoxidase levels in sAGP-treated rats
compared with nsAGP-treated rats. Complement-dependent intestinal
injury, assessed by 125I-albumin permeability was reduced
by 28% (P < 0.05) in animals treated with sAGP
(7.58 ± 0.63) compared with those treated with nsAGP
(10.4 ± 0.54). We conclude that sAGP ameliorates both complement- and neutrophil-mediated injuries.
complement; lung; neutrophils; selectins; sialyl Lewisx
This article has been cited by other articles:
|
|
 |
|
  C. M. Shing, J. Peake, K. Suzuki, M. Okutsu, R. Pereira, L. Stevenson, D. G. Jenkins, and J. S. Coombes Effects of bovine colostrum supplementation on immune variables in highly trained cyclists J Appl Physiol, March 1, 2007; 102(3): 1113 - 1122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Hochepied, A Wullaert, F G Berger, H Baumann, P Brouckaert, L Steidler, and C Libert Overexpression of {alpha}1-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis Gut, September 1, 2002; 51(3): 398 - 404. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. A. R. C. Daemen, V. H. Heemskerk, C. van 't Veer, G. Denecker, T. G. A. M. Wolfs, P. Vandenabeele, and W. A. Buurman Functional Protection by Acute Phase Proteins {alpha}1-Acid Glycoprotein and {alpha}1-Antitrypsin Against Ischemia/Reperfusion Injury by Preventing Apoptosis and Inflammation Circulation, September 19, 2000; 102(12): 1420 - 1426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. VAN DEN HEUVEL, D. C. W. POLAND, C. S. DE GRAAFF, E. C. M. HOEFSMIT, P. E. POSTMUS, R. H. J. BEELEN, and W. VAN DIJK The Degree of Branching of the Glycans of alpha 1-Acid Glycoprotein in Asthma . A Correlation with Lung Function and Inflammatory Parameters Am. J. Respir. Crit. Care Med., June 1, 2000; 161(6): 1972 - 1978. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. Hochepied, W. Van Molle, F. G. Berger, H. Baumann, and C. Libert Involvement of the Acute Phase Protein alpha 1-Acid Glycoprotein in Nonspecific Resistance to a Lethal Gram-negative Infection J. Biol. Chem., May 12, 2000; 275(20): 14903 - 14909. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Fournier, N. Bouach, C. Delafosse, B. Crestani, and M. Aubier Inducible Expression and Regulation of the {alpha}1-Acid Glycoprotein Gene by Alveolar Macrophages: Prostaglandin E2 and Cyclic AMP Act as New Positive Stimuli J. Immunol., September 1, 1999; 163(5): 2883 - 2890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Boncela, I. Papiewska, I. Fijalkowska, B. Walkowiak, and C. S. Cierniewski Acute Phase Protein alpha 1-Acid Glycoprotein Interacts with Plasminogen Activator Inhibitor Type 1 and Stabilizes Its Inhibitory Activity J. Biol. Chem., September 14, 2001; 276(38): 35305 - 35311. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
