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Am J Physiol Gastrointest Liver Physiol 273: G979-G981, 1997;
0193-1857/97 $5.00
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Vol. 273, Issue 5, G979-G981, November 1997

THEME
V. Transcriptional regulation, development, and neoplasia of the intestinal epithelium*

Peter G. Traber

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

Coordination of gene transcription is a critical regulatory step in orchestrating developmental, differentiation, and adaptation processes in the mammalian intestinal epithelium. An understanding of the regulatory network of nuclear proteins that direct transcriptional initiation of intestinal genes will provide insight into the mechanisms of normal development and differentiation as well as disease processes such as neoplasia.

transcriptome; intestinal mucosa; neoplasia; sucrase-isomaltase

* Fifth in a series of invited articles on Epithelial Cell Growth and Differentiation.




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