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Am J Physiol Gastrointest Liver Physiol 273: G982-G986, 1997;
0193-1857/97 $5.00
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Vol. 273, Issue 5, G982-G986, November 1997

THEME
II. Leukocyte-endothelial cell adhesion in the digestive system*

D. Neil Granger

Department of Molecular and Cellular Physiology, Louisiana State University Medical Center, Shreveport, Louisiana 71130-3932

The adhesion of leukocytes to vascular endothelial cells is a highly coordinated process that is governed by a number of factors, including the expression of specific adhesion glycoproteins, physical forces generated within the microcirculation, and inflammatory mediators released by a variety of activated cells. The digestive system, with its large resident population of immune cells and its tremendous capacity to generate inflammatory mediators, has proven to be a valuable source of information on the mechanisms involved in the regulation of leukocyte-endothelial cell adhesion. This article considers some of the evolving issues that have surfaced as a consequence of the rapidly growing body of literature on this topic. Particular emphasis is devoted to unresolved issues related to the expression and shedding of endothelial cell adhesion molecules, the contribution of capillaries to the inflammatory response, and the role of mast cells, macrophages, and lymphocytes in the modulation of leukocyte-endothelial cell adhesion.

capillaries; mast cells; macrophages; lymphocytes; inflammatory response; intercellular adhesion molecule-1

* Second in a series of invited articles on Cell Adhesion and Migration.




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