| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Molecular and Cellular Physiology, Louisiana State University Medical Center, Shreveport, Louisiana 71130-3932
The adhesion of leukocytes to vascular endothelial cells is a highly coordinated process that is governed by a number of factors, including the expression of specific adhesion glycoproteins, physical forces generated within the microcirculation, and inflammatory mediators released by a variety of activated cells. The digestive system, with its large resident population of immune cells and its tremendous capacity to generate inflammatory mediators, has proven to be a valuable source of information on the mechanisms involved in the regulation of leukocyte-endothelial cell adhesion. This article considers some of the evolving issues that have surfaced as a consequence of the rapidly growing body of literature on this topic. Particular emphasis is devoted to unresolved issues related to the expression and shedding of endothelial cell adhesion molecules, the contribution of capillaries to the inflammatory response, and the role of mast cells, macrophages, and lymphocytes in the modulation of leukocyte-endothelial cell adhesion.
capillaries; mast cells; macrophages; lymphocytes; inflammatory response; intercellular adhesion molecule-1
This article has been cited by other articles:
|
|
 |
|
  O. A. Hatoum, H. Miura, and D. G. Binion The vascular contribution in the pathogenesis of inflammatory bowel disease Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H1791 - H1796. [Full Text] [PDF]
|
|
|
|
 |
|
 V. Zaninovic, A. S. Gukovskaya, I. Gukovsky, M. Mouria, and S. J. Pandol Cerulein upregulates ICAM-1 in pancreatic acinar cells, which mediates neutrophil adhesion to these cells Am J Physiol Gastrointest Liver Physiol, October 1, 2000; 279(4): G666 - G676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Russell, C. J. Epstein, M. B. Grisham, J. S. Alexander, K.-Y. Yeh, and D. N. Granger Regulation of E-selectin expression in postischemic intestinal microvasculature Am J Physiol Gastrointest Liver Physiol, June 1, 2000; 278(6): G878 - G885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. CUZZOCREA, T. P. MISKO, G. COSTANTINO, E. MAZZON, A. MICALI, A. P. CAPUTI, H. MACARTHUR, and D. SALVEMINI Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion FASEB J, June 1, 2000; 14(9): 1061 - 1072. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. G. Wood, J. S. Johnson, L. F. Mattioli, and N. C. Gonzalez Systemic hypoxia promotes leukocyte-endothelial adherence via reactive oxidant generation J Appl Physiol, November 1, 1999; 87(5): 1734 - 1740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kawachi, A. Cockrell, F. S. Laroux, L. Gray, D. N. Granger, H. C. van der Heyde, and M. B. Grisham Role of inducible nitric oxide synthase in the regulation of VCAM-1 expression in gut inflammation Am J Physiol Gastrointest Liver Physiol, September 1, 1999; 277(3): G572 - G576. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
