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1 Gastroenterology Research Unit and 2 Section of Biostatistics, Mayo Clinic, Rochester, Minnesota 55905
The effects of
pharmacological modulation of adrenergic receptors on colonic motor and
sensory function are unclear. We studied 40 healthy volunteers in a
single-blind design; 12 received saline, and the remaining 28 received
either clonidine, yohimbine, phenylephrine, or ritodrine. A
barostat-manometric assembly in the left colon recorded drug effects on
fasting and postprandial motor function, compliance, and sensation in
response to standardized phasic balloon distensions delivered in random
order. Clonidine reduced and yohimbine increased fasting, but not
postprandial tone, by 63.2 ± 22.3% and 24.8 ± 8.8% (SE),
respectively. Clonidine tended to reduce fasting phasic activity in the
descending and sigmoid colon. A power exponential model provided the
best fit to the compliance curve. Clonidine significantly increased
colonic compliance. Clonidine reduced and yohimbine increased colonic
perception of pain but not gas sensation during distension.
Phenylephrine and ritodrine did not influence colonic motor or sensory
function in the present studies. Thus
2-receptors modulate fasting
colonic tone and compliance and alter perception of pain but not gas
during mechanical stimulation of the colon.
colonic tone; sensation; compliance
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