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1 London Health Sciences Centre Research, Inc., London, Ontario, Canada N6A 4G5; and 2 Department of Molecular and Cellular Physiology, Louisiana State University Medical Center, Shreveport, Louisiana 70533-3932
Endothelial cells contribute to a variety of biological responses that facilitate organ function. This critical role of the endothelial cell has resulted in the development of different in vitro models that utilize monolayers of cultured cells to simulate conditions that exist in the intact animal. This review focuses on endothelial cell monolayers as a model system for research on certain pathophysiological conditions affecting the gastrointestinal tract. The advantages and limitations of endothelial cell monolayers are addressed, along with evolving technologies and strategies that hold promise for extending the utility of this in vitro model for studies of gastrointestinal function and disease.
ischemia-reperfusion; nonsteroidal anti-inflammatory drugs; nitric oxide; human umbilical vein endothelial cells; leukocyte migration; monolayer permeability; neutrophils
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