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Am J Physiol Gastrointest Liver Physiol 274: G7-G9, 1998;
0193-1857/98 $5.00
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Vol. 274, Issue 1, G7-G9, January 1998

THEME
I. Antigen presentation in the intestine: new rules and regulations*

Lloyd Mayer

Immunobiology Center, Mount Sinai Medical Center, New York, New York 10029

The recognition that immune responses in the intestine differ from those seen systemically has led to a search for novel pathways involved in mucosal immunoregulation. One cell type that has surfaced as a prime candidate for such a regulatory role is the intestinal epithelial cell. A number of laboratories have documented that intestinal epithelial cells sample luminal antigens and process and present these to primed T cells. However, several unique features have emerged, making their potential role as antigen-presenting cells a critical part of mucosal homeostasis.

intestinal epithelium; antigen presentation; nonclassical major histocompatibility complex

* First in a series of invited articles on Current Concepts in Mucosal Immunity.




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