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Department of Pediatrics and The Wexner Institute for Pediatric Research, Children's Hospital, Columbus, Ohio 43205
The responses of buffer-perfused terminal
mesenteric arteries from 3- and 35-day-old swine to manipulation of
intravascular pressure and flow rate were determined. Under in vivo
conditions, these vessels demonstrated age-dependent differences in
resting diameter (182 vs. 301 µm in 3- vs. 35-day-old swine). A
proximal-to-distal pressure gradient was present in vessels from both
age groups (
13 vs. 16 mmHg in 3- vs. 35-day-old swine),
suggesting their functional role as resistance vessels. Vessels
were mounted within an in vitro perfusion apparatus that allowed
independent regulation of inflow and outflow pressure. Vessels from
both age groups demonstrated the development of active tone in response
to an incremental rise in pressure, applied in the absence of flow.
However, myogenic vasoconstriction was only observed in younger
arterioles. Similarly, both groups demonstrated dilation in response to
a flow stimulus generated in the absence of a net change in
intravascular pressure, although the magnitude of this response was
significantly greater in younger vessels (+27 vs. +7% in 3- vs.
35-day-old swine). The dilatory response to flow was eliminated by
NG-monomethyl-L-arginine
(10
4 M) but restored by
coadministration of L-arginine
(103 M). Myogenic
vasoconstriction was overridden by flow-mediated dilation in terminal
mesenteric arteries from 3- but not 35-day-old swine after concomitant
application of pressure and flow stimuli. We conclude that the
hemodynamic characteristics of terminal mesenteric arteries are age
dependent in postnatal swine.
intestinal circulation; newborn; microvasculature; oxygen delivery; blood flow
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