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Am J Physiol Gastrointest Liver Physiol 274: G459-G464, 1998;
0193-1857/98 $5.00
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Vol. 274, Issue 3, G459-G464, March 1998

Tonic and phasic motor activity in the proximal and distal colon of healthy humans

Pauline Jouet, Benoît Coffin, Marc Lémann, Caroline Gorbatchef, Claire Franchisseur, Raymond Jian, Jean-Claude Rambaud, and Bernard Flourié

Unité de Recherche sur les Fonctions Intestinales, le Métabolisme et la Nutrition, Institut National de la Santé et de la Recherche Médicale Unité 290, Hôpital Saint-Lazare and Hôpital Saint-Louis, 75010 Paris, France

In healthy humans, meals stimulate phasic and tonic motor activity in the unprepared distal colon. The response of the proximal colon remains unknown. In this study, we assessed the effect of a liquid meal on proximal and distal colonic motor activity. In 12 healthy volunteers, colonic tone and phasic motility were simultaneously recorded by using an electronic barostat and perfused catheters in the fasting state and in response to a 1,000-kcal meal. The meal significantly increased the phasic activity in the distal colon (230 ± 46% of the basal value; P = 0.02) but not in the proximal colon (138 ± 25% of the basal value; P = 0.2). The intrabag volume of the barostat was significantly more reduced in the distal than in the proximal colon (74 ± 11 vs. 50 ± 9% of the basal values, respectively; P = 0.04). We conclude that the postprandial response of the unprepared proximal colon is an immediate tonic contraction that is less pronounced than in the distal colon.

barostat; colonic motility; colonic tone


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