AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 274: G614-G617, 1998;
0193-1857/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lamm, M. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lamm, M. E.
Vol. 274, Issue 4, G614-G617, April 1998

THEMES
Current Concepts in Mucosal Immunity
IV. How epithelial transport of IgA antibodies relates to host defense*

Michael E. Lamm

Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106

The humoral arm of the mucosal immune system is principally composed of locally synthesized polymeric IgA, whose Fc portion is adapted for binding to the polymeric immunoglobulin receptor that is expressed on the basolateral surface of mucosal epithelial cells, including enterocytes. This receptor mediates the endocytosis and transcytosis of polymeric IgA, which allows IgA to function in host defense at three anatomic levels in relation to mucosal epithelium: IgA antibodies in the lamina propria can bind antigens and excrete them through the epithelium into the lumen; antiviral IgA antibodies in transit through epithelial cells can inhibit virus production by an intracellular action; and IgA antibodies secreted into the lumen can prevent antigens and microbes from adhering to and penetrating the epithelium. The ways in which IgA antibodies function in mucous membranes provide challenging investigative opportunities for cell physiologists and cell biologists.

polymeric immunoglobulin receptor; epithelial transcytosis; mucosal defense

* Fourth in a series of invited articles on Current Concepts in Mucosal Immunity.




This article has been cited by other articles:


Home page
 Physiol. GenomicsHome page
C. M. T. Dvorak, G. N. Hirsch, K. A. Hyland, J. A. Hendrickson, B. S. Thompson, M. S. Rutherford, and M. P. Murtaugh
Genomic dissection of mucosal immunobiology in the porcine small intestine
Physiol Genomics, December 13, 2006; 28(1): 5 - 14.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
P. L. TUMA and A. L. HUBBARD
Transcytosis: Crossing Cellular Barriers
Physiol Rev, July 1, 2003; 83(3): 871 - 932.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
R. M. Hershberg
The Epithelial Cell Cytoskeleton and Intracellular Trafficking: V. Polarized compartmentalization of antigen processing and Toll-like receptor signaling in intestinal epithelial cells
Am J Physiol Gastrointest Liver Physiol, October 1, 2002; 283(4): G833 - G839.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
J NEUBERGER
PBC and the gut: the villi atrophy, the plot thickens
Gut, May 1, 1999; 44(5): 594 - 595.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online